853136-76-2
Chemical Structure
Autophagonizer
Synonym(s): DK-1-49
- CAS No.: 853136-76-2
- Formula:C28H31N5O3S2
- Molecular Weight:549.71
IUPAC Name: 2-(((3-benzyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)methyl)-N-(2-(pyrrolidin-1-yl)ethyl)oxazole-4-carboxamide
InChIKey: BCMZCPIZJPKEIR-UHFFFAOYSA-N
SMILES: O=C(C1=COC(CSC2=NC3=C(C4=C(CCCC4)S3)C(N2CC5=CC=CC=C5)=O)=N1)NCCN6CCCC6
Biological Activity: Autophagonizer (DK-1-49) is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and enhances levels of autophagosomes and acidic vacuoles. Autophagonizer inhibits cell viability and induces cell death in not only cancer cells but also Bax/Bak double-knockout cells with EC50 values of 3-4 μM[1].
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Autophagonizer | Autophagonizer (DK-1-49) is a small molecule autophagy inducer that results in an accumulation of autophagy-associated LC3-II and enhances levels of autophagosomes and acidic vacuoles. Autophagonizer inhibits cell viability and induces cell death in not only cancer cells but also Bax/Bak double-knockout cells with EC50 values of 3-4 μM. | |||||||||||||||||||||
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Keywords
