cGMP-HTL
Based on 1 Customer Validation
cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity.
For research use only. We do not sell to patients.
- Purity: 99.71%
- Formula: C31H51ClN7O14PS
- Molecular Weight:844.27
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
cGMP-HTL (10 μM, 24 h) selective degrades S-guanylated EGFP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cells expressing EGFP-HT protein.
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Concentration:10 μM.
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Incubation Time:0-24 h.
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Result:Decrease in cGMP-modified EGFP and intact EGFP levels.
Chemical Information
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Appearance Solid
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Molecular Weight 844.27
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Formula C31H51ClN7O14PS
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Color White to off-white
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SMILES
NC(N1)=NC2=C(N=C(SC[C@H](NC(C)=O)C(NCCOCCOCCOCCOCCOCCCCCCCl)=O)N2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](CO4)O3)C1=O
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Synonyms
cGMP-HaloTag-ligand
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (118.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1845 mL | 5.9223 mL | 11.8446 mL | 29.6114 mL |
| 5 mM | 0.2369 mL | 1.1845 mL | 2.3689 mL | 5.9223 mL | |
| 10 mM | 0.1184 mL | 0.5922 mL | 1.1845 mL | 2.9611 mL | |
| 15 mM | 0.0790 mL | 0.3948 mL | 0.7896 mL | 1.9741 mL | |
| 20 mM | 0.0592 mL | 0.2961 mL | 0.5922 mL | 1.4806 mL | |
| 25 mM | 0.0474 mL | 0.2369 mL | 0.4738 mL | 1.1845 mL | |
| 30 mM | 0.0395 mL | 0.1974 mL | 0.3948 mL | 0.9870 mL | |
| 40 mM | 0.0296 mL | 0.1481 mL | 0.2961 mL | 0.7403 mL | |
| 50 mM | 0.0237 mL | 0.1184 mL | 0.2369 mL | 0.5922 mL | |
| 60 mM | 0.0197 mL | 0.0987 mL | 0.1974 mL | 0.4935 mL | |
| 80 mM | 0.0148 mL | 0.0740 mL | 0.1481 mL | 0.3701 mL | |
| 100 mM | 0.0118 mL | 0.0592 mL | 0.1184 mL | 0.2961 mL |
cGMP-HTL Related Classifications
HY-133869 Related Classifications
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