1. Autophagy
  2. Autophagy
  3. cGMP-HTL

cGMP-HTL (Synonyms: cGMP-HaloTag-ligand)

Cat. No.: HY-133869
Handling Instructions

cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity.

For research use only. We do not sell to patients.

cGMP-HTL Chemical Structure

cGMP-HTL Chemical Structure

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Description

cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity[1].

In Vitro

cGMP-HTL (10 μM, 24 h) selective degrades S-guanylated EGFP[1].

Western Blot Analysis[1]

Cell Line: HeLa cells expressing EGFP-HT protein.
Concentration: 10 μM.
Incubation Time: 0-24 h.
Result: Decrease in cGMP-modified EGFP and intact EGFP levels.
Molecular Weight

844.27

Formula

C₃₁H₅₁ClN₇O₁₄PS

SMILES

NC(N1)=NC2=C(N=C(SC[[email protected]](NC(C)=O)C(NCCOCCOCCOCCOCCOCCCCCCCl)=O)N2[[email protected]]3[[email protected]](O)[[email protected]](OP4(O)=O)[[email protected]@H](CO4)O3)C1=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

cGMP-HTLcGMP-HaloTag-ligandAutophagyAUTAC,Inhibitorinhibitorinhibit

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