1. Autophagy
  2. Autophagy
  3. cGMP-HTL

cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity.

For research use only. We do not sell to patients.

cGMP-HTL Chemical Structure

cGMP-HTL Chemical Structure

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Description

cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity[1].

In Vitro

cGMP-HTL (10 μM, 24 h) selective degrades S-guanylated EGFP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells expressing EGFP-HT protein.
Concentration: 10 μM.
Incubation Time: 0-24 h.
Result: Decrease in cGMP-modified EGFP and intact EGFP levels.
Molecular Weight

844.27

Formula

C31H51ClN7O14PS

SMILES

NC(N1)=NC2=C(N=C(SC[C@H](NC(C)=O)C(NCCOCCOCCOCCOCCOCCCCCCCl)=O)N2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](CO4)O3)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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cGMP-HTL Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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cGMP-HTL
Cat. No.:
HY-133869
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