1. Autophagy
  2. Autophagy
  3. DC661

DC661 

Cat. No.: HY-111621
Handling Instructions

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity.

For research use only. We do not sell to patients.

DC661 Chemical Structure

DC661 Chemical Structure

CAS No. : 1872387-43-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 267 In-stock
Estimated Time of Arrival: December 31
2 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 370 In-stock
Estimated Time of Arrival: December 31
25 mg USD 730 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Technical Information

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Description

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity[1].

IC50 & Target

PPT1, autophagy[1]

In Vitro

DC661 (0.1 and 10 µM) accumulates autophagic vesicles in melanoma cells[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (113.11 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8097 mL 9.0485 mL 18.0969 mL
5 mM 0.3619 mL 1.8097 mL 3.6194 mL
10 mM 0.1810 mL 0.9048 mL 1.8097 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

552.58

Formula

C₃₁H₃₉Cl₂N₅

CAS No.

1872387-43-3

SMILES

CN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34

Shipping

Room temperature in continental US; may vary elsewhere

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
DC661
Cat. No.:
HY-111621
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DC661

Cat. No.: HY-111621