1. Autophagy
  2. Autophagy
  3. EACC

EACC 

Cat. No.: HY-129111 Purity: 99.25%
Handling Instructions

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.

For research use only. We do not sell to patients.

EACC Chemical Structure

EACC Chemical Structure

CAS No. : 864941-31-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 285 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 425 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1530 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1].

IC50 & Target

Autophagy[1]

In Vitro

EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function[1].
EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes[1].
EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17[1].

Molecular Weight

369.37

Formula

C₁₃H₁₁N₃O₆S₂

CAS No.

864941-31-1

SMILES

O=C(OCC)NC(C1=C(NC(C2=CC=C([N+]([O-])=O)S2)=O)SC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.88 mg/mL (45.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7073 mL 13.5366 mL 27.0731 mL
5 mM 0.5415 mL 2.7073 mL 5.4146 mL
10 mM 0.2707 mL 1.3537 mL 2.7073 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.69 mg/mL (4.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

EACCAutophagyInhibitorinhibitorinhibit

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EACC
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HY-129111
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