1. Autophagy
  2. Autophagy
  3. EACC

EACC 

Cat. No.: HY-129111
Handling Instructions

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.

For research use only. We do not sell to patients.

EACC Chemical Structure

EACC Chemical Structure

CAS No. : 864941-31-1

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Description

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1].

IC50 & Target

Autophagy[1]

In Vitro

EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function[1].
EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes[1].
EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17[1].

Molecular Weight

369.37

Formula

C₁₃H₁₁N₃O₆S₂

CAS No.

864941-31-1

SMILES

O=C(OCC)NC(C1=C(NC(C2=CC=C([N+]([O-])=O)S2)=O)SC=C1)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EACC
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