2. Autophagy
  3. Autophagy
  4. EACC

EACC 

Cat. No.: HY-129111 Purity: 99.72%
COA Handling Instructions

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.

For research use only. We do not sell to patients.

EACC Chemical Structure

EACC Chemical Structure

CAS No. : 864941-31-1

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Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 285 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 285 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 425 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1530 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1].

IC50 & Target

Autophagy[1]
In Vitro

EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function[1].
EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes[1].
EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

369.37

Appearance

Solid

Formula

C13H11N3O6S2
CAS No.
SMILES

O=C(OCC)NC(C1=C(NC(C2=CC=C([N+]([O-])=O)S2)=O)SC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.88 mg/mL (45.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7073 mL 13.5366 mL 27.0731 mL
5 mM 0.5415 mL 2.7073 mL 5.4146 mL
10 mM 0.2707 mL 1.3537 mL 2.7073 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.69 mg/mL (4.58 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

EACC864941-31-1AutophagyInhibitorinhibitorinhibit

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