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Cat. No.: HY-W714048

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Laduviglusib-d₄

(Synonyms: CHIR-99021-d₄; CT99021-d₄)

Laduviglusib-d₄ (CHIR-99021-d₄) is the deuterium labeled Laduviglusib (HY-10182). Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC₅₀s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₄D₄Cl₂N₈
Molecular Weight:469.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Laduviglusib-d₄ Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Wnt Isoforms :

All GSK-3 Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 252917-06-9
Molecular Weight 469.36
Formula C₂₂H₁₄D₄Cl₂N₈
SMILES

ClC1=CC=C(C2=C(C=NC(NC([2H])(C([2H])(NC3=CC=C(C=N3)C#N)[2H])[2H])=N2)C4=NC(C)=CN4)C(Cl)=C1
Synonyms

CHIR-99021-d₄; CT99021-d₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.