2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. Gefitinib impurity 5

Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.

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Gefitinib impurity 5 Chemical Structure

Gefitinib impurity 5 Chemical Structure

CAS No. : 199327-61-2

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Description

Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

Molecular Weight

319.36

Formula

C16H21N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC=NC2=C1C=C(OCCCN3CCOCC3)C(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 97.43%

COA (246 KB) HNMR (116 KB) RP-HPLC (192 KB)

Handling Instructions (2659 KB)
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Gefitinib impurity 5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gefitinib impurity 5199327-61-2Gefitinib impurity5Gefitinib impurity-5Drug MetaboliteInhibitorinhibitorinhibit

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