199327-61-2
Chemical Structure
Gefitinib impurity 5
- CAS No.: 199327-61-2
- Formula:C16H21N3O4
- Molecular Weight:319.36
IUPAC Name: 7-methoxy-6-(3-morpholinopropoxy)quinazolin-4(3H)-one
InChIKey: WFUBWLXSYCFZEH-UHFFFAOYSA-N
SMILES: O=C1NC=NC2=C1C=C(OCCCN3CCOCC3)C(OC)=C2
Biological Activity: Gefitinib impurity 5 is the impurity of Gefitinib (HY-133779). Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces Autophagy. Gefitinib has antitumour activity[1][2].
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Gefitinib impurity 5 | 99.46% | Gefitinib impurity 5 is the impurity of Gefitinib (HY-133779). Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces Autophagy. Gefitinib has antitumour activity. | ||||||||||||||||||||
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Gefitinib impurity 5 (Standard) | ≥98% | Gefitinib impurity 5 (Standard) is the analytical standard of Gefitinib impurity 5. This product is intended for research and analytical applications. Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity. | ||||||||||||||||||||
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