Diquat-d8(dibromide)
Based on 1 Customer Validation
Diquat-d8 dibromide is a deuterium labeled Diquat dibromide (HY-122984). Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds.
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- Formule: C12H4D8Br2N2
- Masse moléculaire:352.09
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 85-00-7
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Masse moléculaire 352.09
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Formule C12H4D8Br2N2
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SMILES
[2H]C1=[N+]2C(C3=[N+](C([2H])=C(C([2H])=C3[2H])[2H])CC2)=C(C([2H])=C1[2H])[2H].[Br-].[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Moreland D E. Mechanisms of action of herbicides. 1980.
[2]. Cao S, et al. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci. 2018 May 4;96(5):1795-1805. [Content Brief]
[3]. Singh P, et al. Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Parkinsons Dis. 2017;2017:2643587. [Content Brief]
[4]. Tomášek O, et al. Opposing effects of oxidative challenge and carotenoids on antioxidant status and condition-dependent sexual signalling. Sci Rep. 2016 Mar 22;6:23546. [Content Brief]
[5]. Nisar R, et al. Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria. Arch Toxicol. 2015 Oct;89(10):1811-25. [Content Brief]
[6]. Zhang JQ, et al. Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice. PLoS One. 2016 Jan 19;11(1):e0147075. [Content Brief]
[7]. Karuppagounder SS, et al. Investigate the chronic neurotoxic effects of diquat. Neurochem Res. 2012 May;37(5):1102-11. [Content Brief]
[8]. Acar A. In vivo toxicological assessment of diquat dibromide: cytotoxic, genotoxic, and biochemical approach. Environ Sci Pollut Res Int. 2021;28(34):47550-47561. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Diquat-d8(dibromide) Related Classifications
HY-W758421 Related Classifications
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