ERK1/2 inhibitor 10
Based on 1 publication(s) in Google Scholar
ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1 and ERK2 inhibitor (IC50: 0.11 and 0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations.
For research use only. We do not sell to patients.
- CAS No.: 3056077-07-4
- Formula: C23H20ClN5O2S
- Molecular Weight:465.96
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ERK1/2 inhibitor 10
More
Biological Activity
|
ERK1 0.11 nM (IC50) |
ERK2 0.8 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
1.16 μM
Compound: 36c
|
Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability incubated for 24 hrs by methyl thiazolyl tetrazolium (MTT) assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell viability incubated for 24 hrs by methyl thiazolyl tetrazolium (MTT) assay
|
[PMID: 38613499] |
| RKO | IC50 |
1.07 μM
Compound: 36c
|
Antiproliferative activity against human RKO cells assessed as cell viability incubated for 24 hrs by methyl thiazolyl tetrazolium (MTT) assay
Antiproliferative activity against human RKO cells assessed as cell viability incubated for 24 hrs by methyl thiazolyl tetrazolium (MTT) assay
|
[PMID: 38613499] |
Chemical Information
-
CAS No. 3056077-07-4
-
Molecular Weight 465.96
-
Formula C23H20ClN5O2S
-
SMILES
O=C(C1=CC(C2=NC(NC3=CC=NC(C)=C3)=NC=C2Cl)=CS1)N[C@@H](C4=CC=CC=C4)CO
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
J Dairy Sci
Immunomodulatory effects, digestive stability, and action mechanism of casein peptide SPAQILQW in activating macrophages via N-terminal serine. [Abstract]2025 Apr 28:S0022-0302(25)00284-X. PMID: 40306417
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERK1/2 inhibitor 10 Related Classifications
HY-162460 Related Classifications
Powered by Bioz