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Art. -Nr.: HY-116071

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Autophagy-IN-3

Name: Autophagy-IN-3
Brand: MedChemExpress
SKU: HY-116071
Price: 215.00 USD
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Autophagy-IN-3 (Compound 6k) is an autophagy inhibitor. Autophagy-IN-3 promotes metabolic stress in the tumor microenvironment and enhances the effects of cytostatics in combined treatments.

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CAS. Nr.: 1227476-98-3
Formel: C₂₂H₁₈Cl₂N₂O₃
Molecular Weight:429.30

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Autophagy-IN-3 Chemical Structure

CAS. Nr.: 1227476-98-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Publications (1)
Reinheit & Dokumentation
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Calculators
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Bioz

Biologische Aktivität

Beschreibung

Autophagy-IN-3 (Compound 6k) is an autophagy inhibitor. Autophagy-IN-3 promotes metabolic stress in the tumor microenvironment and enhances the effects of cytostatics in combined treatments^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
G-361	IC₅₀	1.3 μM Compound: 6k	Cytotoxicity against human G361 cells after 72 hrs by calcein-AM assay Cytotoxicity against human G361 cells after 72 hrs by calcein-AM assay	[PMID: 23981532]
HCT-116	IC₅₀	1.7 μM Compound: 6k	Cytotoxicity against human HCT116 cells after 72 hrs by calcein-AM assay Cytotoxicity against human HCT116 cells after 72 hrs by calcein-AM assay	[PMID: 23981532]
HeLa	IC₅₀	1.1 μM Compound: 6k	Cytotoxicity against human HeLa cells after 72 hrs by calcein-AM assay Cytotoxicity against human HeLa cells after 72 hrs by calcein-AM assay	[PMID: 23981532]
HOS	IC₅₀	2.5 μM Compound: 6k	Cytotoxicity against human HOS cells after 72 hrs by calcein-AM assay Cytotoxicity against human HOS cells after 72 hrs by calcein-AM assay	[PMID: 23981532]
K562	IC₅₀	2.5 μM Compound: 6k	Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay	[PMID: 23981532]
MCF7	IC₅₀	3.5 μM Compound: 6k	Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay	[PMID: 23981532]

Chemical Information

CAS. Nr. 1227476-98-3
Molecular Weight 429.30
Formel C₂₂H₁₈Cl₂N₂O₃
SMILES

O=C(C1=CC(Cl)=CC=C1O)N[C@H](CC2=CC=CC=C2)C(NC3=CC=C(C=C3)Cl)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2025 Nov 3.

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Páchniková G, et al. Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux. Toxicol In Vitro. 2016 Dec;37:70-78. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Autophagy-IN-3

1 Cited Publications

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Biologische Aktivität
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Chemical Information
Publications (1)
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Autophagy-IN-3

Publications Citing Use of MedChemExpress (MCE) Autophagy-IN-3