Autophagy-IN-3
Based on 1 publication(s) in Google Scholar
Autophagy-IN-3 (Compound 6k) is an autophagy inhibitor. Autophagy-IN-3 promotes metabolic stress in the tumor microenvironment and enhances the effects of cytostatics in combined treatments.
For research use only. We do not sell to patients.
- CAS No.: 1227476-98-3
- Formula: C22H18Cl2N2O3
- Molecular Weight:429.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Autophagy-IN-3
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| G-361 | IC50 |
1.3 μM
Compound: 6k
|
Cytotoxicity against human G361 cells after 72 hrs by calcein-AM assay
Cytotoxicity against human G361 cells after 72 hrs by calcein-AM assay
|
[PMID: 23981532] |
| HCT-116 | IC50 |
1.7 μM
Compound: 6k
|
Cytotoxicity against human HCT116 cells after 72 hrs by calcein-AM assay
Cytotoxicity against human HCT116 cells after 72 hrs by calcein-AM assay
|
[PMID: 23981532] |
| HeLa | IC50 |
1.1 μM
Compound: 6k
|
Cytotoxicity against human HeLa cells after 72 hrs by calcein-AM assay
Cytotoxicity against human HeLa cells after 72 hrs by calcein-AM assay
|
[PMID: 23981532] |
| HOS | IC50 |
2.5 μM
Compound: 6k
|
Cytotoxicity against human HOS cells after 72 hrs by calcein-AM assay
Cytotoxicity against human HOS cells after 72 hrs by calcein-AM assay
|
[PMID: 23981532] |
| K562 | IC50 |
2.5 μM
Compound: 6k
|
Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
|
[PMID: 23981532] |
| MCF7 | IC50 |
3.5 μM
Compound: 6k
|
Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
|
[PMID: 23981532] |
Chemical Information
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CAS No. 1227476-98-3
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Molecular Weight 429.30
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Formula C22H18Cl2N2O3
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SMILES
O=C(C1=CC(Cl)=CC=C1O)N[C@H](CC2=CC=CC=C2)C(NC3=CC=C(C=C3)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)