10-Hydroxydecanoic acid (Standard)
10-Hydroxydecanoic acid (Standard) is the analytical standard of 10-Hydroxydecanoic acid. This product is intended for research and analytical applications. 10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 1679-53-4
- Formula: C10H20O3
- Molecular Weight:188.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 1679-53-4
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Molecular Weight 188.26
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Formula C10H20O3
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SMILES
O=C(O)CCCCCCCCCO
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Synonyms
NSC 15139 (Standard); 10-HDAA (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Takahashi K, et al. Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages. Biomed Res. 2013 Aug;34(4):205-14. [Content Brief]
[2]. Isayama, et al. "10-Hydroxydecanoic acid potentially elicits antigen-specific IgA responses." Biological and Pharmaceutical Bulletin 43.8 (2020): 1202-1209. [Content Brief]
[3]. Alkhaibari, et al. Insecticidal, antimalarial, and antileishmanial effects of royal jelly and its three main fatty acids, trans‐10‐hydroxy‐2‐decenoic acid, 10‐hydroxydecanoic acid, and sebacic acid. Evidence‐Based Complementary and Alternative Medicine 2022.1 (2022): 7425322. [Content Brief]
[4]. Mengmeng, et al. "10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells." International Immunopharmacology 84 (2020): 106501. [Content Brief]
[5]. Mengmeng, et al. "Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation." Food & Function 13.4 (2022): 2336-2353. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
10-Hydroxydecanoic acid (Standard) Related Classifications
HY-Y0148R Related Classifications
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