TSPO ligand-1
Based on 1 Customer Validation
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 4560-08-1
- Formula: C16H10ClNO2
- Molecular Weight:283.71
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice[2].
TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells[3].
TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4560-08-1
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Appearance Solid
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Molecular Weight 283.71
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Formula C16H10ClNO2
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Color Light yellow to green yellow
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SMILES
O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (582 KB)
- English - EN (582 KB)
- Français - FR (582 KB)
- Deutsch - DE (582 KB)
- Norwegian - NO (582 KB)
- Español - ES (582 KB)
- Swedish - SV (582 KB)
- Italian - IT (582 KB)
- Korean - KR (582 KB)
- Portuguese - PT (582 KB)
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Handling Instructions (2659 KB)
References
[1]. Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10. [Content Brief]
[2]. Tina Notter, et al. Neuronal activity increases translocator protein (TSPO) levels. Mol Psychiatry. 2021 Jun;26(6):2025-2037. doi: 10.1038/s41380-020-0745-1. Epub 2020 May 12. [Content Brief]
[3]. Benjamin B Tournier, et al. Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer's Disease. J Alzheimers Dis. 2020;77(3):1043-1056. doi: 10.3233/JAD-200136. [Content Brief]
[4]. Lan N Tu, et al. Translocator Protein (TSPO) Affects Mitochondrial Fatty Acid Oxidation in Steroidogenic Cells. Endocrinology. 2016 Mar;157(3):1110-21. doi: 10.1210/en.2015-1795. Epub 2016 Jan 7. [Content Brief]
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TSPO ligand-1 Related Classifications
HY-150407 Related Classifications
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