4560-08-1
Chemical Structure
TSPO ligand-1
- CAS No.: 4560-08-1
- Formula:C16H10ClNO2
- Molecular Weight:283.71
IUPAC Name: 2-oxo-2-(2-phenyl-1H-indol-3-yl)acetyl chloride
InChIKey: DREHVYWKTXGDBS-UHFFFAOYSA-N
SMILES: O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl
Biological Activity: TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration[1][2].
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TSPO ligand-1 | 98.0% | TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration. | ||||||||||||||||||||
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References
- [1]. Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10. [Content Brief]
- [2]. Tina Notter, et al. Neuronal activity increases translocator protein (TSPO) levels. Mol Psychiatry. 2021 Jun;26(6):2025-2037. doi: 10.1038/s41380-020-0745-1. Epub 2020 May 12. [Content Brief]
