ATG2A Antibody (YA4320)(PBS only)
(Synonyms: KIAA0404, ATG2A, Autophagy-related protein 2 homolog A)ATG2A Antibody (YA4320) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATG2A.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:50-1:200 | 1:200-1:400 | 1:10000 |
Product Details
ATG2A Antibody (YA4320) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATG2A.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 215 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 212.8 kDa
Purified recombinant fragment of human ATG2A (AA: 325-429) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ATG2A is a Lipid transfer protein involved in autophagosome assembly. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Also regulates lipid droplets morphology and distribution within the cell[1][2][3][4].
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Subcellular Localization
Preautophagosomal structure membrane; Peripheral membrane protein; Lipid droplet; Endoplasmic reticulum membrane; Peripheral membrane protein
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Isoforms & Post-Translational Modification
Q2TAZ0 has 4 isomers: Q2TAZ0-1: 212860 Da (predicted); Q2TAZ0-3: 213087 Da (predicted); Q2TAZ0-4: 35255 Da (predicted); Q2TAZ0-5: 13576 Da (predicted).
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Subunit
Interacts with ATG9A (via C-terminus) (PubMed:32610138, PubMed:33106659, PubMed:33850023). Interacts (via WIPI-interacting region) with WDR45B/WIPI3 (PubMed:32483132). Interacts (via WIPI-interacting region) with WDR45/WIPI4 (PubMed:28820312, PubMed:32483132). Interacts with TMEM41B (PubMed:33850023). Interacts with VMP1 (PubMed:33850023)
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SwissProt ID
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Synonyms
KIAA0404, ATG2A, Autophagy-related protein 2 homolog A
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