ATG2A - autophagy related 2A Gene

Also Known as BLTP4A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23130

About ATG2A

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,894,546-64,917,209 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 17.3), spleen (RPKM 4.8) and 25 other tissues.

Summary

Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in autophagosome assembly. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in phagophore assembly site. Predicted to be extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATG2A Products (3)

mRNA Protein Name
NM_001367971.1 NP_001354900.1 autophagy-related protein 2 homolog A isoform 2
NM_001367972.1 NP_001354901.1 autophagy-related protein 2 homolog A isoform 3
NM_015104.3 NP_055919.2 autophagy-related protein 2 homolog A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipid transfer activity IDA
IDA: Inferred from direct assay
30952800 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20562859 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
28561066 GOA
involved in positive regulation of autophagosome assembly IDA
IDA: Inferred from direct assay
30952800 GOA
Cellular Component GO Annotation Evidence References Source
is active in organelle membrane contact site IDA
IDA: Inferred from direct assay
30952800 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG2A Protein Structure

Chorein_N

Chorein_N: N-terminal region of Chorein or VPS13 (16 - 109)

ATG_C

ATG_C: Autophagy-related protein C terminal domain (1837 - 1932)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1938 a.a.
Protein Preferred Names Protein Names

autophagy-related protein 2 homolog A

  • ATG2 autophagy related 2 homolog A

ATG2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATG2A Q2TAZ0 TOMM40 Homo sapiens O96008
Anti Bait CoIP
31412244
Intra
ATG2A Q2TAZ0 TOMM40 Homo sapiens O96008
Anti Tag CoIP
31412244
Intra
ATG2A Q2TAZ0 TOMM40 Homo sapiens O96008
Crosslink
31412244
Intra
ATG2A Q2TAZ0 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
ATG2A Q2TAZ0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ATG2A Q2TAZ0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ATG2A Q2TAZ0 WDR45 Homo sapiens Q9Y484
Anti Tag CoIP
31412244
Intra
ATG2A Q2TAZ0 WDR45 Homo sapiens Q9Y484
Anti Tag CoIP
20562859
Intra
ATG2A Q2TAZ0 MAP1LC3B Homo sapiens Q9GZQ8
Pull Down
20562859
Intra
ATG2A Q2TAZ0 GABARAP Homo sapiens O95166
Pull Down
20562859
Intra
ATG2A Q2TAZ0 GABARAPL2 Homo sapiens P60520
Pull Down
20562859
Intra
ATG2A Q2TAZ0 ATG9A Homo sapiens Q7Z3C6
Anti Tag CoIP
31412244
Intra
ATG2A Q2TAZ0 GABARAPL1 Homo sapiens Q9H0R8
Pull Down
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

ATG2A Antibodies

Cat. No. Product Name Application Reactivity
HY-P84623 ATG2A Antibody (YA4320) ICC/IF, FC, ELISA Human
HY-P84623A ATG2A Antibody (YA4320)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

  • Nbia

  • Neurodegeneration With Brain Iron Accumulation Disorders

  • Neurodegeneration, With Brain Iron Accumulation
Neurodegeneration With Brain Iron Accumulation 5

  • NBIA5

  • Beta-Propeller Protein-Associated Neurodegeneration

  • Bpan

  • Static Encephalopathy Of Childhood With Neurodegeneration In Adulthood

  • Senda

  • Neurodegeneration With Brain Iron Accumulation Type 5

  • Neurodegeneration With Brain Iron Accululation 5

  • Static Encephalopathy Of Childhood With Neurdegeneration In Adulthood

  • Neurodegeneration, With Brain Iron Accululation, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01145 ATG2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATG2A VGNC VGNC:60000
Rattus norvegicus ATG2A RGD RGD:1589890
Bos taurus ATG2A VGNC VGNC:106645
Macaca mulatta ATG2A VGNC VGNC:70145
Canis familiaris ATG2A VGNC VGNC:38221
Mus musculus ATG2A MGD MGI:1916291
Others ATG2A NCBI