2. Autophagy JAK/STAT Signaling
  3. Autophagy Pim
  4. NDBM

NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation.

For research use only. We do not sell to patients.

NDBM Chemical Structure

NDBM Chemical Structure

CAS No. : 2958641-42-2

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NDBM Related Antibodies

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Description

NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation[1].

IC50 & Target

Pim-1[1]
In Vivo

NDBM (10 μM, 30 mins) has lower fluorescence intensity in normal cells (HUVEC, RAW 264.7 cell line) than tumor cells (MGC-803, HepG2 and Hela cell lines) [1].
NDBM (2.5, 5, 10 and 20 μM, 18 h) decreases the survival rate of tumor cells (MGC-803, HepG2 and Hela) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

679.56

Formula

C33H35BrN4O7
CAS No.
SMILES

BrC1=CC=C2OC(C(NCCOCCOCCN3C(C4=C5C(C(NCCN6CCOCC6)=CC=C5C3=O)=CC=C4)=O)=O)=CC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NDBM Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDBM 2958641-42-2AutophagyPimPim kinasesPim-1 kinaseAnticancerMGC-803HepG2HelaInhibitorinhibitorinhibit

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