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Maprotiline hydrochloride 

Cat. No.: HY-B0444 Purity: 99.97%
Handling Instructions

Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant.

For research use only. We do not sell to patients.

Maprotiline hydrochloride Chemical Structure

Maprotiline hydrochloride Chemical Structure

CAS No. : 10347-81-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 120 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. Target: Others Maprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). However, Maprotiline's fourth ring is spurious, as formed by a bridge across the central tricyclic ring. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts strong blocking effect at H1 receptors, moderate at 5-HT2 and alpha1 and weak blocking effect at D2 and mACh postsynaptic receptors [1, 2].

Clinical Trial
Molecular Weight

313.86

Formula

C₂₀H₂₄ClN

CAS No.

10347-81-6

SMILES

CNCCCC1(CC2)C3=CC=CC=C3C2C4=CC=CC=C14.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (318.61 mM; Need ultrasonic)

H2O : 2.2 mg/mL (7.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1861 mL 15.9307 mL 31.8613 mL
5 mM 0.6372 mL 3.1861 mL 6.3723 mL
10 mM 0.3186 mL 1.5931 mL 3.1861 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.97 mM); Clear solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MaprotilineAutophagyInhibitorinhibitorinhibit

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Product Name:
Maprotiline hydrochloride
Cat. No.:
HY-B0444
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