Maprotiline-d3 hydrochloride
Based on 1 Customer Validation
Maprotiline-d3 (hydrochloride) is deuterium labeled Maprotiline (hydrochloride).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.80%
- CAS No.: 1329496-63-0
- 화학식: C20H21D3ClN
- 분자량:316.88
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1329496-63-0
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Unlabeled Cas 10347-81-6
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Appearance Solid
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분자량 316.88
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화학식 C20H21D3ClN
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Color White to off-white
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SMILES
[2H]C([2H])([2H])NCCCC12C3=CC=CC=C3C(CC2)C4=CC=CC=C41.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 83.33 mg/mL (262.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2.2 mg/mL (6.94 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Peng, W.H., et al., Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice. Life Sci, 2007. 81(11): p. 933-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.1558 mL | 15.7788 mL | 31.5577 mL | 78.8942 mL |
| 5 mM | 0.6312 mL | 3.1558 mL | 6.3115 mL | 15.7788 mL | |
| DMSO | 10 mM | 0.3156 mL | 1.5779 mL | 3.1558 mL | 7.8894 mL |
| 15 mM | 0.2104 mL | 1.0519 mL | 2.1038 mL | 5.2596 mL | |
| 20 mM | 0.1578 mL | 0.7889 mL | 1.5779 mL | 3.9447 mL | |
| 25 mM | 0.1262 mL | 0.6312 mL | 1.2623 mL | 3.1558 mL | |
| 30 mM | 0.1052 mL | 0.5260 mL | 1.0519 mL | 2.6298 mL | |
| 40 mM | 0.0789 mL | 0.3945 mL | 0.7889 mL | 1.9724 mL | |
| 50 mM | 0.0631 mL | 0.3156 mL | 0.6312 mL | 1.5779 mL | |
| 60 mM | 0.0526 mL | 0.2630 mL | 0.5260 mL | 1.3149 mL | |
| 80 mM | 0.0394 mL | 0.1972 mL | 0.3945 mL | 0.9862 mL | |
| 100 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.7889 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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