10347-81-6
10347-81-6
Chemical Structure
Maprotiline hydrochloride
- CAS No.: 10347-81-6
- Formula:C20H24ClN
- Molecular Weight:313.86
IUPAC Name: 3-(9,10-ethanoanthracen-9(10H)-yl)-N-methylpropan-1-amine hydrochloride
InChIKey: NZDMFGKECODQRY-UHFFFAOYSA-N
SMILES: CNCCCC1(CC2)C3=CC=CC=C3C2C4=CC=CC=C14.Cl
Biological Activity: Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].
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Maprotiline hydrochloride | 99.84% | Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1. | ||||||||||||||||||||
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Maprotiline hydrochloride (Standard) | 99.99% | Maprotiline (hydrochloride) (Standard) is the analytical standard of Maprotiline (hydrochloride). Maprotiline (hydrochloride) (Standard) is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline (hydrochloride) (Standard) induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1. | ||||||||||||||||||||
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Maprotiline-d5 hydrochloride | Maprotiline-d5 (hydrochloride) is the deuterium labeled Maprotiline hydrochloride. Maprotiline hydrochloride is a selective noradrenalin re-uptake inhibitor and a tetracyclic antidepressant. | |||||||||||||||||||||
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Maprotiline-d3 hydrochloride | 98.80% | Maprotiline-d3 (hydrochloride) is deuterium labeled Maprotiline (hydrochloride). | ||||||||||||||||||||
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References
- [1]. Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767. [Content Brief]
- [2]. Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20(3):465-71.
