2. Metabolic Enzyme/Protease Apoptosis Autophagy
  3. Aldehyde Dehydrogenase (ALDH) Apoptosis Autophagy
  4. AD-9308

AD-9308 is a highly selective and orally active ALDH2 activator. AD-9308 activates ALDH2 to promote the clearance of 4-HNE, inhibiting myocardial fibrosis, inflammation and cell apoptosis. AD-9308 improves mitochondrial function, sarcoplasmic reticulum/ endoplasmic reticulum calcium transport and regulates autophagy, restoring intracellular homeostasis. AD-9308 improves the diastolic and systolic function of the heart in diabetic mice and reverses ventricular mal-reconstruction. AD-9308 can be used for the study of diabetic cardiomyopathy.

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AD-9308

AD-9308 Chemical Structure

CAS No. : 1804942-56-0

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AD-9308 Related Antibodies

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Description

AD-9308 is a highly selective and orally active ALDH2 activator. AD-9308 activates ALDH2 to promote the clearance of 4-HNE, inhibiting myocardial fibrosis, inflammation and cell apoptosis. AD-9308 improves mitochondrial function, sarcoplasmic reticulum/ endoplasmic reticulum calcium transport and regulates autophagy, restoring intracellular homeostasis. AD-9308 improves the diastolic and systolic function of the heart in diabetic mice and reverses ventricular mal-reconstruction. AD-9308 can be used for the study of diabetic cardiomyopathy[1].

Molecular Weight

537.62

Formula

C30H36FN3O5
CAS No.
SMILES

CC(C)[C@H](N)C(OCC1=C(C2=CC(C(NCC3=CC(F)=C(C=C3)OC)=O)=C(C=C2)OCC(C)C)N=CC=C1)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AD-9308 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD-93081804942-56-0AD9308AD 9308Aldehyde Dehydrogenase (ALDH)ApoptosisAutophagyAldehyde dehydrogenase 2 (ALDH2)Diabetic cardiomyopathy4-Hydroxy-2-nonenal (4-HNE)Streptozotocin (STZ)Oxidative stressCardiac functionFibrosisMitochondrial function.Inhibitorinhibitorinhibit

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