1804942-56-0
Chemical Structure
AD-9308
- CAS No.: 1804942-56-0
- Formula:C30H36FN3O5
- Molecular Weight:537.62
InChIKey: OCBSJBZAJKSJNI-MHZLTWQESA-N
SMILES: CC(C)[C@H](N)C(OCC1=C(C2=CC(C(NCC3=CC(F)=C(C=C3)OC)=O)=C(C=C2)OCC(C)C)N=CC=C1)=O
Biological Activity: AD-9308 is a highly selective and orally active ALDH2 activator. AD-9308 activates ALDH2 to promote the clearance of 4-HNE, inhibiting myocardial fibrosis, inflammation and cell apoptosis. AD-9308 improves mitochondrial function, sarcoplasmic reticulum/ endoplasmic reticulum calcium transport and regulates autophagy, restoring intracellular homeostasis. AD-9308 improves the diastolic and systolic function of the heart in diabetic mice and reverses ventricular mal-reconstruction. AD-9308 can be used for the study of diabetic cardiomyopathy[1].
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AD-9308 | AD-9308 is a highly selective and orally active ALDH2 activator. AD-9308 activates ALDH2 to promote the clearance of 4-HNE, inhibiting myocardial fibrosis, inflammation and cell apoptosis. AD-9308 improves mitochondrial function, sarcoplasmic reticulum/ endoplasmic reticulum calcium transport and regulates autophagy, restoring intracellular homeostasis. AD-9308 improves the diastolic and systolic function of the heart in diabetic mice and reverses ventricular mal-reconstruction. AD-9308 can be used for the study of diabetic cardiomyopathy. | |||||||||||||||||||||
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Keywords
