1804942-56-0
Chemical Structure
AD-9308
- CAS No.: 1804942-56-0
- Formula:C30H36FN3O5
- Molecular Weight:537.62
InChIKey: OCBSJBZAJKSJNI-MHZLTWQESA-N
SMILES: CC(C)[C@H](N)C(OCC1=C(C2=CC(C(NCC3=CC(F)=C(C=C3)OC)=O)=C(C=C2)OCC(C)C)N=CC=C1)=O
Biological Activity: AD-9308 is an orally active, highly selective aldehyde dehydrogenase 2 (ALDH2) activator. AD-9308 alleviates oxidative stress, improves mitochondrial function, restores cell viability, reduces renal tubular injury, fibrosis and inflammatory responses, reverses ventricular remodeling, restores the activities of Dicer and superoxide dismutase, inhibits the IL-6 signaling pathway, reduces the accumulation of 4-HNE-protein adducts, and improves glucose homeostasis. AD-9308 can be used in studies related to acrolein-induced kidney injury, diabetes, cardiomyopathy, heart failure, diet-induced obesity, fatty liver, insulin resistance and glucose intolerance[1][2][3][4][5].
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AD-9308 | AD-9308 is an orally active, highly selective aldehyde dehydrogenase 2 (ALDH2) activator. AD-9308 alleviates oxidative stress, improves mitochondrial function, restores cell viability, reduces renal tubular injury, fibrosis and inflammatory responses, reverses ventricular remodeling, restores the activities of Dicer and superoxide dismutase, inhibits the IL-6 signaling pathway, reduces the accumulation of 4-HNE-protein adducts, and improves glucose homeostasis. AD-9308 can be used in studies related to acrolein-induced kidney injury, diabetes, cardiomyopathy, heart failure, diet-induced obesity, fatty liver, insulin resistance and glucose intolerance. | |||||||||||||||||||||
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References
- [1]. Kuo YM, et al. Aldehyde dehydrogenase 2 mitigates acrolein-driven ferroptosis to preserve kidney function. Environmental pollution (Barking, Essex : 1987). 2026 Feb 01;390:127555. [Content Brief]
- [2]. Lee HL, et al. A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice. Antioxidants (Basel, Switzerland). 2021 Mar 13;10(3):450. [Content Brief]
- [3]. Kiyuna LA, et al. 4-Hydroxynonenal impairs miRNA maturation in heart failure via Dicer post-translational modification. European heart journal. 2023 Nov 21;44(44):4696-4712. [Content Brief]
- [4]. Chou YH, et al. Deciphering endothelial aldehyde dehydrogenase 2, oxidative stress, and interleukin-6 interactions in pulmonary hypertension: Implications for precision medicine. Biochemical pharmacology. 2026 Jan;243(Pt 1):117510. [Content Brief]
- [5]. Chang YC, et al. A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators. Nature communications. 2023 Sep 25;14(1):5971. [Content Brief]
