2. Autophagy Anti-infection
  3. Autophagy Antibiotic
  4. Elaiophylin

Elaiophylin  (Synonyms: Azalomycin B; Gopalamicin; Efomycin E)

Cat. No.: HY-15184 Purity: 96.20%
COA Handling Instructions

Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) is an autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells.

For research use only. We do not sell to patients.

Elaiophylin Chemical Structure

Elaiophylin Chemical Structure

CAS No. : 37318-06-2

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10 mM * 1 mL in DMSO USD 586 In-stock
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5 mg USD 320 In-stock
10 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

Elaiophylin Related Antibodies

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Description

Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) is an autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells[1].

IC50 & Target

Autophagy[1]
In Vitro

Elaiophylin-mediated autophagy inhibition and lysosomal dysfunction affect ovarian cancer cell survival during hypoxia. Exposure to Elaiophylin (0.025-0.5 μM; 24 hours) causes a significant increase in ovarian cancer SKOV3 cell death in hypoxia conditions[1].
In both the SKOV3 and A2780 cell lines, Elaiophylin (0.25, 0.5, 0.75 μM; 24 hours) treatment leads to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Elaiophylin Related Antibodies

Cell Viability Assay[1]

Cell Line: Ovarian cancer SKOV3 cells.
Concentration: 0.025, 0.05, 0.1, 0.2, 0.5 μM
Incubation Time: 24 hours
Result: Caused a significant increase in ovarian cancer SKOV3 cells death in hypoxia conditions.

Western Blot Analysis[1]

Cell Line: Ovarian cancer SKOV3 cells; A2780 cells
Concentration: 0.25, 0.5, 0.75 μM
Incubation Time: 24 hours
Result: Treatment led to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner.
In Vivo

Treatment with 2 mg/kg Elaiophylin (given i.p. every 2 days for 21 days; in BALB/C athymic mice) significantly suppresses ovarian cancer SKOV3 cells growth compared with DMSO treatment, resulting in a 72% decrease in the average daily tumor growth rate compared with DMSO treatment [1].
Lower doses of Elaiophylin as a single agent exert significant antitumor activity, while higher doses lead to intestinal toxicity. Administration of a lower dose (2 mg/kg) of Elaiophylin as a single agent achieves a significant antitumor effect without toxicity in an orthotopic ovarian cancer model with metastasis. Toxic reactions are observed only in the 8 mg/kg group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-wk-old BALB/C athymic mice with ovarian cancer SKOV3 cells[1]
Dosage: 1 or 2 mg/kg
Administration: Given i.p. every 2 days for 21 days
Result: Treatment with 2 mg/kg significantly suppressed ovarian cancer SKOV3 cells growth compared with DMSO treatment.
Molecular Weight

1025.27

Appearance

Solid

Formula

C54H88O18
CAS No.
SMILES

C[C@H]1[C@@H](O)[C@@H](O)C[C@H](O[C@@H]2C[C@@]([C@H]([C@H](O)[C@H](C)[C@](OC(/C=C/C=C/[C@H](C)[C@]([C@@H](C)[C@@H](O)[C@@H]([C@]3(O)O[C@H](C)[C@@H](CC)[C@H](O[C@H]4C[C@H](O)[C@H](O)[C@H](C)O4)C3)C)([H])OC5=O)=O)([H])[C@H](/C=C/C=C/5)C)C)(O)O[C@H](C)[C@H]2CC)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 96.20%

COA (260 KB)

Handling Instructions (2659 KB)
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Elaiophylin Related Classifications

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Keywords:

Elaiophylin37318-06-2Azalomycin B Gopalamicin Efomycin EAutophagyAntibioticInhibitorinhibitorinhibit

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