Doxazosin hydrochloride

(Synonyms: UK 33274 hydrochloride)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Doxazosin hydrochloride (UK 33274 hydrochloride) is a compound used to inhibit hypertension and prostate hyperplasia, with activity that inhibits postsynaptic α1-adrenoceptors on vascular smooth muscle. Doxazosin hydrochloride can cause vasodilation, thereby reducing peripheral vascular resistance. Doxazosin hydrochloride was found to inhibit the proliferation and migration of hepatic stellate cells in a mouse liver fibrosis model. Doxazosin hydrochloride regulates fibrosis, autophagy, and apoptosis of hepatic stellate cells by activating the PI3K/Akt/mTOR signaling pathway. Doxazosin hydrochloride also blocks autophagic flux and induces apoptosis of hepatic stellate cells.

For research use only. We do not sell to patients.

  • CAS No.: 70918-01-3
  • Formula: C23H26ClN5O5
  • Molecular Weight:487.94
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

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