2. Apoptosis Autophagy
  3. Autophagy Apoptosis
  4. UCM-1336

UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis.

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UCM-1336 Chemical Structure

UCM-1336 Chemical Structure

CAS No. : 1621535-90-7

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UCM-1336 Related Antibodies

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Description

UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1].

IC50 & Target

IC50: 2 μM (2 μM)[1].
Molecular Weight

423.59

Formula

C26H37N3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(CCN(CCCCCCCC)CCC(NC1=CC=CC=C1)=O)NC2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (236.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3608 mL 11.8039 mL 23.6077 mL
5 mM 0.4722 mL 2.3608 mL 4.7215 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3608 mL 11.8039 mL 23.6077 mL 59.0193 mL
5 mM 0.4722 mL 2.3608 mL 4.7215 mL 11.8039 mL
10 mM 0.2361 mL 1.1804 mL 2.3608 mL 5.9019 mL
15 mM 0.1574 mL 0.7869 mL 1.5738 mL 3.9346 mL
20 mM 0.1180 mL 0.5902 mL 1.1804 mL 2.9510 mL
25 mM 0.0944 mL 0.4722 mL 0.9443 mL 2.3608 mL
30 mM 0.0787 mL 0.3935 mL 0.7869 mL 1.9673 mL
40 mM 0.0590 mL 0.2951 mL 0.5902 mL 1.4755 mL
50 mM 0.0472 mL 0.2361 mL 0.4722 mL 1.1804 mL
60 mM 0.0393 mL 0.1967 mL 0.3935 mL 0.9837 mL
80 mM 0.0295 mL 0.1475 mL 0.2951 mL 0.7377 mL
100 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5902 mL
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UCM-1336 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UCM-13361621535-90-7UCM1336UCM 1336AutophagyApoptosisICMTRasapoptosisautophagyInhibitorinhibitorinhibit

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