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  3. SLLN-15

SLLN-15 

Cat. No.: HY-125465
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SLLN-15 is an oral active, selective and potent enhancer of autophagy that activates cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC).

For research use only. We do not sell to patients.

SLLN-15 Chemical Structure

SLLN-15 Chemical Structure

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Description

SLLN-15 is an oral active, selective and potent enhancer of autophagy that activates cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC)[1].

In Vitro

SLLN-15 (0, 1, 5, 10, 25 μM) treatment for 24 h markedly decreases overall cell viability of breast cancer cells in a dose-dependent manner[1].
SLLN-15 (100 nM and 1000 nM, 7 days) is able to equally inhibit the colony formation abilities of several breast cancer cell lines[1].
Overall, SLLN-15 induces a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux. This induction is associated with a selective inhibition of AKT-MTOR signaling.

Cell Viability Assay[1]

Cell Line: TNBC cell lines BT-20 and MDA-MB-231.
Concentration: 0, 1, 5, 10, 25 μM.
Incubation Time: 24 hours.
Result: Inhibited the proliferation of two TNBC cell lines, BT-20 and MDA-MB-231.

Cell Viability Assay[1]

Cell Line: TNBC cell lines (MDA-MB-231, BT-20, 4T1, MDA-MB-468), MCF-7 (ERBB2-), SKBR-3 (ERBB2+) and HEK293T.
Concentration: 100 nM and 1000 nM.
Incubation Time: 7 days.
Result: Equally inhibited the colony formation abilities of several breast cancer cell lines.
In Vivo

SLLN-15 (30mg/kg, PO, 3 times a week) not only inhibits the growth of TNBC in animal model, but also TNBC cell progression to metastases[1].
Overall, oral SLLN-15 reveals a potent anticancer and anti-metastatic activity in mice bearing TNBC[1].

Animal Model: BALB/c mice or SCID mice transplanted with mouse mammary carcinoma 4T1 cells and human breast adenocarcinoma MDA-MB-231 cells (1 X 106 cells/ each mouse)[1]
Dosage: 30mg/kg.
Administration: PO, 3 times a week for 40 days.
Result: Tumor allografts grew at a slower rate compared to control groups.
Significant inhibition of the number of lung metastases as visualized.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

507.35

Formula

C₁₉H₂₃N₇Se₂

SMILES

C12=NC(NC3=CC=C(N4CC[Se]CC4)C=C3)=NC(N[[email protected]@H]5C[Se]CC5)=C1N=CN2

Shipping

Room temperature in continental US; may vary elsewhere

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SLLN-15
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SLLN-15

Cat. No.: HY-125465