1. Autophagy
  2. Autophagy
  3. SLLN-15

SLLN-15 

Cat. No.: HY-125465
Handling Instructions

SLLN-15 is an oral active, selective and potent enhancer of autophagy that activates cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC).

For research use only. We do not sell to patients.

SLLN-15 Chemical Structure

SLLN-15 Chemical Structure

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Description

SLLN-15 is an oral active, selective and potent enhancer of autophagy that activates cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC)[1].

In Vitro

SLLN-15 (0, 1, 5, 10, 25 μM) treatment for 24 h markedly decreases overall cell viability of breast cancer cells in a dose-dependent manner[1].
SLLN-15 (100 nM and 1000 nM, 7 days) is able to equally inhibit the colony formation abilities of several breast cancer cell lines[1].
Overall, SLLN-15 induces a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux. This induction is associated with a selective inhibition of AKT-MTOR signaling.

Cell Viability Assay[1]

Cell Line: TNBC cell lines BT-20 and MDA-MB-231.
Concentration: 0, 1, 5, 10, 25 μM.
Incubation Time: 24 hours.
Result: Inhibited the proliferation of two TNBC cell lines, BT-20 and MDA-MB-231.

Cell Viability Assay[1]

Cell Line: TNBC cell lines (MDA-MB-231, BT-20, 4T1, MDA-MB-468), MCF-7 (ERBB2-), SKBR-3 (ERBB2+) and HEK293T.
Concentration: 100 nM and 1000 nM.
Incubation Time: 7 days.
Result: Equally inhibited the colony formation abilities of several breast cancer cell lines.
In Vivo

SLLN-15 (30mg/kg, PO, 3 times a week) not only inhibits the growth of TNBC in animal model, but also TNBC cell progression to metastases[1].
Overall, oral SLLN-15 reveals a potent anticancer and anti-metastatic activity in mice bearing TNBC[1].

Animal Model: BALB/c mice or SCID mice transplanted with mouse mammary carcinoma 4T1 cells and human breast adenocarcinoma MDA-MB-231 cells (1 X 106 cells/ each mouse)[1]
Dosage: 30mg/kg.
Administration: PO, 3 times a week for 40 days.
Result: Tumor allografts grew at a slower rate compared to control groups.
Significant inhibition of the number of lung metastases as visualized.
Molecular Weight

507.35

Formula

C₁₉H₂₃N₇Se₂

SMILES

C12=NC(NC3=CC=C(N4CC[Se]CC4)C=C3)=NC(N[[email protected]@H]5C[Se]CC5)=C1N=CN2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SLLN-15
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