1. Anti-infection
    Apoptosis
    Autophagy
  2. Bacterial
    Apoptosis
    Autophagy
  3. Pogostone

Pogostone 

Cat. No.: HY-N1416
Handling Instructions

Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml . Pogostone induces cell apoptosis and autophagy.

For research use only. We do not sell to patients.

Pogostone Chemical Structure

Pogostone Chemical Structure

CAS No. : 23800-56-8

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Description

Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml [2]. Pogostone induces cell apoptosis and autophagy[2].

IC50 & Target

IC50: apoptosis; autophagy; bacteria[1][2]

In Vitro

Pogostone shows inhibitory effects on HCT116 cell with an IC50 value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC50: 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC50: 112±20.77 µg/ml)[1].

In Vivo

Pogostone ( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively[2].

Molecular Weight

224.25

Formula

C₁₂H₁₆O₄

CAS No.

23800-56-8

SMILES

O=C1C(C(CCC(C)C)=O)=C(O)C=C(C)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PogostoneBacterialApoptosisAutophagygram negativegram positiveapoptosiscorynebacterium xerosis autophagyInhibitorinhibitorinhibit

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