1. Anti-infection
    Apoptosis
    Autophagy
  2. Bacterial
    Apoptosis
    Autophagy
  3. Pogostone

Pogostone 

Cat. No.: HY-N1416 Purity: 99.70%
Handling Instructions

Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml . Pogostone induces cell apoptosis and autophagy.

For research use only. We do not sell to patients.

Pogostone Chemical Structure

Pogostone Chemical Structure

CAS No. : 23800-56-8

Size Price Stock Quantity
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 270 In-stock
Estimated Time of Arrival: December 31
100 mg USD 460 Get quote
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Pogostone is isolated from patchouli with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml [2]. Pogostone induces cell apoptosis and autophagy[2].

IC50 & Target

IC50: apoptosis; autophagy; bacteria[1][2]

In Vitro

Pogostone shows inhibitory effects on HCT116 cell with an IC50 value of 18.7±1.93 µg/ml, and show strikingly lower cytotoxicity on normal human embryonic kidney cell 293A (IC50: 95.13±19.44 µg/ml) and endothelial cell HUVEC (IC50: 112±20.77 µg/ml)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pogostone ( intraperitoneal injection; 25, 50 and 100 mg/kg) shows antibacterial activity in vivo against Escherichia coli (E. coli) and MRSA. Ninety percent of the mice infected with E. coil could be protected at the concentrations of 50 and 100 mg/kg, and 60% of the mice at 25 mg/kg, while the rate of protection for the mice infected with MRSA was 60% and 50% at doses of 100 and 50 mg/kg, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

224.25

Formula

C₁₂H₁₆O₄

CAS No.
SMILES

O=C1C(C(CCC(C)C)=O)=C(O)C=C(C)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (445.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4593 mL 22.2965 mL 44.5931 mL
5 mM 0.8919 mL 4.4593 mL 8.9186 mL
10 mM 0.4459 mL 2.2297 mL 4.4593 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PogostoneBacterialApoptosisAutophagygram negativegram positiveapoptosiscorynebacterium xerosis autophagyInhibitorinhibitorinhibit

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