1. Cell Cycle/DNA Damage
    Epigenetics
    Anti-infection
    Autophagy
    Apoptosis
  2. HDAC
    HIV
    Autophagy
    Apoptosis
  3. Panobinostat lactate

Panobinostat lactate (Synonyms: LBH589 lactate; NVP-LBH589 lactate)

Cat. No.: HY-10224A
Handling Instructions

Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma.

For research use only. We do not sell to patients.

Panobinostat lactate Chemical Structure

Panobinostat lactate Chemical Structure

CAS No. : 960055-56-5

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Top Publications Citing Use of Products

34 Publications Citing Use of MCE Panobinostat lactate

    Panobinostat lactate purchased from MCE. Usage Cited in: China Biotechnology. 2016, 36(6): 9-17.

    The HDAC expression of PC3 cell with different concentration of Panobinostat. (a) HDACs mRNA expression is analyzed by real time PCR (b) HDACs protein expression is analyzed by Western blot.

    Panobinostat lactate purchased from MCE. Usage Cited in: PLoS Pathog. 2018 Sep 13;14(9):e1007267. 

    Immunoblot analysis for vIL-6, ORF45, or actin is performed on lysates from BCBL-1 cells treated with NaB+TPA, Romidepsin or Panobinostat.
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    Description

    Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma[1][2][3][4][5].

    IC50 & Target

    HDAC

     

    HIV-1

     

    In Vitro

    Panobinostat lactate induces apoptosis of both MOLT-4 and Reh cells in a time- and dose-dependent manner. Panobinosta lactate results in histone (H3K9 and H4K8) hyperacetylation and regulation of cell-cycle control genes in Reh cells[1].
    Panobinostat lactate exhibites potent antiproliferative activity in human NSCLC cell lines with the IC50 ranging from 5 to 100 nM[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Panobinosta lactate (10, 20 mg/kg, i.p.) significantly slows tumor growth derived from Meso and NSCLC cells in vivo models. Panobinosta lactate markedly increases acetylation of histone H3 and H4 of H69 human SCLC cells harvest from SCID mice[2].
    Panobinostat lactate (5, 10 and 20 mg/kg i.p.) demonstrates a clear benefit of decreased tumor burden, significantly improves TTE and reduces bone density loss in a disseminated multiple myeloma mouse model[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    439.50

    Formula

    C24H29N3O5

    CAS No.
    SMILES

    O=C(NO)/C=C/C1=CC=C(CNCCC2=C(C)NC3=C2C=CC=C3)C=C1.OC(C)C(O)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
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    Product Name:
    Panobinostat lactate
    Cat. No.:
    HY-10224A
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