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Panobinostat lactate

(Synonyms: LBH589 lactate; NVP-LBH589 lactate)
86 Cited Publications
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Based on 86 publication(s) in Google Scholar

Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma.

For research use only. We do not sell to patients.

  • Purity: 98.67%
  • CAS No.: 960055-56-5
  • Formula: C24H29N3O5
  • Molecular Weight:439.50
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Panobinostat lactate Chemical Structure
    Panobinostat lactate Chemical Structure
  • Experimental Validation Results for Panobinostat lactate
  • Experimental Validation Results for Panobinostat lactate
  • Experimental Validation Results for Panobinostat lactate
  • Experimental Validation Results for Panobinostat lactate
CAS No.: 960055-56-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Panobinostat lactate Chemical Structure
    Panobinostat lactate Chemical Structure
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    Panobinostat lactate purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Nov 11;41(1):321. [Abstract]

    Customer Validation
     The expression of BRD4 and MYC proteins are each downregulated by JQ1 (0.5 µM; 24 h) or panobinostat (PAN; 10 nM; 24 h) alone, and more profoundly by the combination of these two inhibitors in in MB HD-MB03 and D-283 cells.

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    Panobinostat lactate purchased from MedChemExpress. Usage Cited in: Commun Biol. 2021 Oct 29;4(1):1235. [Abstract]

    Customer Validation
     TNBC model cells (MDA-MB-231 and BT-549) were treated with indicated HDACi (Vorinostat: 10 µM; Panobinostat: 1 µM; Romidepsin: 1 µM; Givinostat: 1 µM) for 24 h and expression of LIFR, p-STAT3(Y705), and STAT3 were determined using Western blotting.

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    Panobinostat lactate purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2018 Sep 13;14(9):e1007267.  [Abstract]

    Customer Validation
     Immunoblot analysis for vIL-6, ORF45, or actin is performed on lysates from BCBL-1 cells treated with NaB+TPA, Romidepsin or Panobinostat.

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    Panobinostat lactate purchased from MedChemExpress. Usage Cited in: China Biotechnology. 2016, 36(6): 9-17.

    Customer Validation
     The HDAC expression of PC3 cell with different concentration of Panobinostat. (a) HDACs mRNA expression is analyzed by real time PCR (b) HDACs protein expression is analyzed by Western blot.

  • Panobinostat lactate