Anti-Ganglioside GD2 Antibody (14G2a) 

Anti-Ganglioside GD2 Antibody (14G2a) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Ganglioside GD2. Anti-Ganglioside GD2 Antibody (14G2a) can induce neuroblastoma cells autophagy and lysis. Anti-Ganglioside GD2 Antibody (14G2a) can be used for the research of cancer, such as neuroblastoma^[1][2].

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Human

Ganglioside GD2

Anti-Ganglioside GD2 Antibody (14G2a) (40 μg/mL, 48 h) induces autophagy in IMR 32 and CHP 134 neuroblastoma cells^[1].
Anti-Ganglioside GD2 Antibody (14G2a) (1 μg/well) induces NMB-7 neuroblastoma target cells lysis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Ganglioside GD2 Antibody (14G2a) (200 μg, i.v., at days 2, 5, 8, 11, 14, 17, 23, 26, 29, 32, 35, 38, 41, and 44) inhibits tumor growth in NMB-7 neuroblastoma mice (BALB/c athymic (nu/nu) mice)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

in vitro induction of apoptosis in GD2+ cells; in vivo inhibition of GD2+ tumor cell growth

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Ganglioside GD2 Antibody (14G2a)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Durbas M, et al. GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells. Apoptosis. 2018 Oct;23(9-10):492-511.  [Content Brief]

  [2]. Mujoo K, et al. Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18. Cancer Res. 1989 Jun 1;49(11):2857-61.  [Content Brief]