PI3K/AKT-IN-3
PI3K/AKT-IN-3 (compound 8C) can induce autophagy and apoptosis by inhibiting the PI3K/AKT signaling pathway. PI3K/AKT-IN-3 can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2488891-30-9
- Formula: C44H63N5O7
- Molecular Weight:774.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
11.9 μM
Compound: 8c
|
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
|
[PMID: 38964258] |
| HeLa | IC50 |
6.07 μM
Compound: 8c
|
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
|
[PMID: 38964258] |
| HepG2 | IC50 |
9.55 μM
Compound: 8c
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
|
[PMID: 38964258] |
| MCF7 | IC50 |
9.78 μM
Compound: 8c
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
|
[PMID: 38964258] |
| PC-3 | IC50 |
10.07 μM
Compound: 8c
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Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38964258] |
| SMMC-7721 | IC50 |
5.02 μM
Compound: 8c
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Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38964258] |
| SW-620 | IC50 |
4.61 μM
Compound: 8c
|
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
Antiproliferative activity against human SW620 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 reagent based spectrophotometric analysis
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[PMID: 38964258] |
Chemical Information
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CAS No. 2488891-30-9
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Molecular Weight 774.00
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Formula C44H63N5O7
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SMILES
COC([C@]12[C@@]([C@@H](CC2)C(C)=C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)(C([C@@H](C5)CC6=CN([C@@H]7[C@H](O[C@@H](N8C(NC(C(C)=C8)=O)=O)C7)CO)N=N6)=O)C)([H])CC4)C)([H])CC3)C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Wang Q, Ma F, Wang J, Xu H, Li K, Cheng YY, Chen X, Qu S, Wei T, Hao X, Kong M, Xie C, Wang W, Wang Y, Jeong LS. Antitumor activity and transcriptome sequencing (RNA-seq) analyses of hepatocellular carcinoma cells in response to exposure triterpene-nucleoside conjugates. Eur J Med Chem. 2024 Jun 28;276:116635. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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