Autophagy inducer 5
Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects.
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- Fòrmula: C41H52N4O3
- Peso molecular:648.88
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
7 μM
Compound: 21o
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| Bel-7402 | IC50 |
3.7 μM
Compound: 21o
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Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| MCF-10A | IC50 |
15.4 μM
Compound: 21o
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Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
| MCF7 | IC50 |
2 μM
Compound: 21o
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 39106494] |
Chemical Information
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Peso molecular 648.88
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Fòrmula C41H52N4O3
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SMILES
O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Autophagy inducer 5 Related Classifications
HY-159605 Related Classifications
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