2. Autophagy MAPK/ERK Pathway Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Autophagy JNK Reactive Oxygen Species (ROS)
  4. Autophagy inducer 5

Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects.

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Autophagy inducer 5

Autophagy inducer 5 Chemical Structure

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Autophagy inducer 5 Related Antibodies

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Description

Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the ROS/JNK signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
7 μM
Compound: 21o
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 39106494]
Bel-7402 IC50
3.7 μM
Compound: 21o
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 39106494]
MCF-10A IC50
15.4 μM
Compound: 21o
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 39106494]
MCF7 IC50
2 μM
Compound: 21o
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 39106494]
Molecular Weight

648.88

Formula

C41H52N4O3
SMILES

O=C([C@]1(C)CC[C@]2(C)CC[C@]3(C)[C@]4(C)C=CC5=C(C)C6=NC7=CC=C(C(NCCN(C)C)=O)C=C7N=C6C=C5C4=CC[C@@]3(C)[C@]2([H])C1)OC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Autophagy inducer 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagy inducer 5Autophagy inducer5Autophagy inducer-5AutophagyJNKReactive Oxygen Species (ROS)c-Jun N-terminal kinaseInhibitorinhibitorinhibit

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