Phytic acid hexalithium
Based on 1 publication(s) in Google Scholar
Phytic acid (Inositol hexaphosphate hexalithium) hexalithium is an orally active compound. Phytic acid hexalithium can be derived from the seeds of legumes. Phytic acid is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid hexalithium attenuates Aβ oligomers and upregulates Autophagy protein. Phytic acid hexalithium can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research.
For research use only. We do not sell to patients.
- Formula: C6H12Li6O24P6
- Molecular Weight:695.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Phytic acid hexalithium
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Biological Activity
Description
In Vitro
Phytic acid (0.05%-0.4% (wt/wt), 5 min) hexalithium and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains[2].
Phytic acid (1-5 mM, 2-3 h) hexalithium decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells[3].
Phytic acid (48-72 h) hexalithium provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells[5].
Phytic acid (≥1 mM) hexalithium stimulates suicidal human erythrocyte death[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2
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Concentration:1, 2, 2.5, 3.5, 5 mM
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Incubation Time:3 h
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Result:Showed over 90% of the cells were viable when IP6 concentrations of 1-5 mM were used during the experiments.
In Vivo
Phytic acid (2%, drinking water, 6 months) hexalithium improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice[5].
Phytic acid (20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) hexalithium suppresses ischemia-induced hydroxyl radical generation in rat myocardium[7].
Phytic acid (100 mg/kg/d, gavage, five days a week, 8 weeks) hexalithium shows protective effects against CCl4-induced liver fibrosis in mice[8].
Phytic acid (4% of rodent chow, diet, 30 days) hexalithium reduces lipogenic enzyme activities in diabetic rats[9].
Phytic acid (1-2 g/100 g, in water, 13 weeks) hexalithium shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively[10].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Piglets with an initial BW of 7.40 kg[4]
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Dosage:2% (Phytic acid/food)
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Administration:diet, 21 days
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Result:Did not affect the blood plasma glucose and Na concentrations.
Reduced total potential difference and total short-circuit current.
Did not affect the blood plasma glucose and Na concentrations.
Did not affect the SGLT1 protein expression.
Chemical Information
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Molecular Weight 695.63
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Formula C6H12Li6O24P6
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SMILES
O=P(O)(O[Li])O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@H]1OP(O)(O[Li])=O)OP(O)([Li][O])=O)OP(O)(O[Li])=O)OP(O)(O[Li])=O)OP(O)([Li][O])=O
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Synonyms
Inositol hexaphosphate hexalithium; SNF472 hexalithium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
[1]. Shears SB, et al.Assessing the omnipotence of inositol hexakisphosphate.Cell Signal. 2001 Mar;13(3):151-8. [Content Brief]
[2]. Kim NH, et al. Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid-Adapted Escherichia coli O157:H7 Strains. Appl Environ Microbiol. 2015 Dec 4;82(4):1040-1049. [Content Brief]
[3]. Fu Q, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci. 2015 Dec 1;80:1-8. [Content Brief]
[4]. Woyengo TA, et al. Effect of dietary phytic acid on performance and nutrient uptake in the small intestine of piglets. J Anim Sci. 2012 Feb;90(2):543-9. [Content Brief]
[5]. Anekonda TS, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23(1):21-35. [Content Brief]
[6]. Eberhard M, et al. Effect of phytic acid on suicidal erythrocyte death. J Agric Food Chem. 2010 Feb 10;58(3):2028-33. [Content Brief]
[7]. Obata T, et al. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Eur J Pharmacol. 2016 Mar 5;774:20-4. [Content Brief]
[9]. Omoruyi FO, et al. The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013:172494. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phytic acid hexalithium Related Classifications
HY-181448 Related Classifications
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