AUTEN-99 hydrobromide (Synonyms: Autophagy enhancer-99 hydrobromide)

Cat. No.: HY-101485: FAQs
Data Sheet Handling Instructions

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AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 (hydrobromide) crosses the blood-brain barrier and exerts potent neuroprotective effects.

For research use only. We do not sell to patients.

AUTEN-99 hydrobromide Chemical Structure

CAS No. : 1049780-58-6

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Purity & Documentation
References
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Description

Molecular Weight

359.28

Formula

C₁₇H₁₅BrN₂S

CAS No.

1049780-58-6

SMILES

[H]Br.C12=NCCN1C=C(C3=CC=C(C4=CC=CC=C4)C=C3)S2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 7.5 mg/mL (20.88 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7833 mL	13.9167 mL	27.8334 mL
5 mM	0.5567 mL	2.7833 mL	5.5667 mL
10 mM	0.2783 mL	1.3917 mL	2.7833 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kovács T, et al. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7833 mL	13.9167 mL	27.8334 mL	69.5836 mL
	5 mM	0.5567 mL	2.7833 mL	5.5667 mL	13.9167 mL
	10 mM	0.2783 mL	1.3917 mL	2.7833 mL	6.9584 mL
	15 mM	0.1856 mL	0.9278 mL	1.8556 mL	4.6389 mL
	20 mM	0.1392 mL	0.6958 mL	1.3917 mL	3.4792 mL

AUTEN-99 hydrobromide Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AUTEN-991049780-58-6Autophagy enhancer-99AUTEN99AUTEN 99Autophagy enhancer99Autophagy enhancer 99OthersInhibitorinhibitorinhibit

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