4-FPBUA
4-FPBUA is a semisynthetic analog of usnic acid (HY-W015883) that can enhance cellular blood-brain barrier (BBB) function and increase the transport of Amyloid β (Aβ) across monolayer cells. 4-FPBUA is also an inhibitor of mTOR, capable of enhancing cellular Autophagy, thereby reversing BBB disruption in vivo and being utilized in research for Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 2089636-93-9
- Formula: C31H23FO7
- Molecular Weight:526.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
0.52 μM
Compound: 40
|
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
|
[PMID: 28245124] |
| MDA-MB-231 | IC50 |
0.68 μM
Compound: 40
|
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
|
[PMID: 28245124] |
Chemical Information
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CAS No. 2089636-93-9
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Molecular Weight 526.51
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Formula C31H23FO7
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SMILES
C[C@]12C3=C(O)C(C)=C(O)C(C(/C=C/C4=CC=C(C5=CC=C(C=C5)F)C=C4)=O)=C3OC1=CC(O)=C(C2=O)C(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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