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27-

" in MedChemExpress (MCE) Product Catalog:

1490

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11

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127

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156

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3

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104

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1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2371
    27-Hydroxycholesterol
    Maximum Cited Publications
    8 Publications Verification

    27-OHC

    		 Estrogen Receptor/ERR LXR Endogenous Metabolite Cancer
    27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.
    27-Hydroxycholesterol
  • HY-P0139
    Gap 27
    5+ Cited Publications

    		 Gap Junction Protein Cardiovascular Disease
    Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .
    Gap 27
  • HY-153006
    2,7-Dichlorodihydrofluorescein
    5+ Cited Publications

    DCFH2

    		 Biochemical Assay Reagents Others
    2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent reactive oxygen species (ROS) probe with an excitation wavelength of 485-500 nm and an emission wavelength of 515-530 nm. 2,7-Dichlorodihydrofluorescein is first hydrolyzed by intracellular esterases and then oxidized by ROS to generate non-biomembrane-permeable, highly fluorescent 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF is positively correlated with the ROS concentration. 2,7-Dichlorodihydrofluorescein can undergo oxidation reactions with a variety of ROS (such as ·OH, H2O2, ONOO -, etc.) and is used to quantitatively detect the level of oxidative stress inside and outside cells. It is suitable for oxidative stress analysis in in vitro cell models and in vivo targeted delivery (such as liver-targeted liposomes) .
    2,7-Dichlorodihydrofluorescein
  • HY-P3508
    PNC-27

    		MDM-2/p53 Cancer
    PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research .
    PNC-27
  • HY-130851
    HS-27

    		HSP Cancer
    HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer .
    HS-27
  • HY-19778
    (R)-BPO-27
    3 Publications Verification

    		 CFTR Autophagy Inflammation/Immunology
    (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM.
    (R)-BPO-27
  • HY-138115
    7ß,27-Dihydroxycholesterol

    7β, 27-OHC

    		 ROR Inflammation/Immunology
    7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4 + Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1 .
    7ß,27-Dihydroxycholesterol
  • HY-18668
    Integrin antagonist 27

    		Integrin Cancer
    Integrin antagonist 27 (Compound 27) is a small molecule integrin αvβ3 antagonist with an affinity of 18 nM. Integrin antagonist 27 can be combined with Paclitaxel (HY-B0015) to selectively target αvβ3-positive metastatic cancer cells. Integrin antagonist 27 is used as an anticancer agent .
    Integrin antagonist 27
  • HY-P3508A
    PNC-27 acetate

    		MDM-2/p53 Cancer
    PNC-27 acetate, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 acetate is an anticancer peptide. PNC-27 acetate can be used in acute myeloid leukemia research .
    PNC-27 acetate
  • HY-P1072
    PHM-27 (human)

    		CGRP Receptor Cardiovascular Disease Metabolic Disease
    PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism .
    PHM-27 (human)
  • HY-143367S
    27-Hydroxy cholesterol-d6

    Cholest-5-ene-3 beta,26-diol-d6

    		 Isotope-Labeled Compounds Others
    27-Hydroxy cholesterol-d6 is deuterium labeled 27-Hydroxy cholesterol.
    27-Hydroxy cholesterol-d6
  • HY-W015451
    2,7-Dihydroxynaphthalene

    2,7-DHN; Naphthalene-2,7-diol

    		 Fungal Others
    2,7-Dihydroxynaphthalene (2,7-DHN) is a substrate of a new group of aromatic prenyltransferases in fungi and can be catalyzed to undergo a regiospecific prenylation reaction. 2,7-Dihydroxynaphthalene can undergo reactions such as oxidation and substitution .
    2,7-Dihydroxynaphthalene
  • HY-142690A
    HDAC-IN-27 dihydrochloride

    		Apoptosis HDAC Cancer
    HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 dihydrochloride exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 dihydrochloride demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 dihydrochloride can be used for research in acute myeloid leukemia (AML) .
    HDAC-IN-27 dihydrochloride
  • HY-142690
    HDAC-IN-27

    		HDAC Apoptosis Cancer
    HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation (AcHH3 and AcHH4). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML) .
    HDAC-IN-27
  • HY-139058
    23-epi-26-Deoxyactein

    27-Deoxyactein

    		 PPAR Metabolic Disease Cancer
    23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound .
    23-epi-26-Deoxyactein
  • HY-34464
    2,7-Dibromocarbazole

    		Biochemical Assay Reagents Others
    2,7-Dibromocarbazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    2,7-Dibromocarbazole
  • HY-N2371R
    27-Hydroxycholesterol (Standard)

    27-OHC (Standard)

    		 Reference Standards Estrogen Receptor/ERR LXR Endogenous Metabolite Cancer
    27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.
    27-Hydroxycholesterol (Standard)
  • HY-P990215
    Anti-Mouse IL-27 p28 Antibody (MM27.7B1)

    		Interleukin Related Infection Inflammation/Immunology
    Anti-Mouse IL-27 p28 Antibody (MM27.7B1) is a mouse-derived anti-mouse IL-27 p28 IgG2a, κ type antibody inhibitor. Anti-Mouse IL-27 p28 Antibody (MM27.7B1) can neutralize IL-27. Anti-Mouse IL-27 p28 Antibody (MM27.7B1) delays CD8+ T cell reconstitution mediated by IL-27 after murine anti-thymocyte globulin (mATG) treatment in BALB/c heart allografts mice models .
    Anti-Mouse IL-27 p28 Antibody (MM27.7B1)
  • HY-159161
    PSB-CB-27

    		Orphan GPCR Inflammation/Immunology Cancer
    PSB-CB-27 is a potent and selective GPR18 inhibitor with an IC50 of 0.65 μM. PSB-CB-27 shows selectivity over Human GPR55, Human CB1 receptor, and Human CB2 receptor. PSB-CB-27 leads to a complete blockade of Δ9-Tetrahydrocannabinol (THC)-induced GPR18 activation. PSB-CB-27 can be used for inflammatory diseases and cancer immunotherapy research .
    PSB-CB-27
  • HY-W045990
    2,7-Dimethylnaphthalene

    		Cytochrome P450 Metabolic Disease
    2,7-Dimethylnaphthalene is a selective cytochrome P450 1A2 (CYP1A2) enzyme inhibitor with an IC50 of 65 μM. 2,7-Dimethylnaphthalene can be used for the research of metabolic disease .
    2,7-Dimethylnaphthalene
  • HY-19778A
    BPO-27 racemate
    1 Publications Verification

    		 CFTR Autophagy Inflammation/Immunology
    BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.
    BPO-27 racemate
  • HY-N15953
    27-Hydroxy oncosterone

    		Drug Metabolite Cancer
    27-Hydroxy oncosterone is a metabolite that inhibits breast cancer (BC) cell proliferation and blocks oncosterone and 27-Hydroxycholesterol (HY-N2371)-induced proliferation in BC cells .
    27-Hydroxy oncosterone
  • HY-P5286
    BMAP-27

    		Bacterial Infection Cancer
    BMAP-27 is an antimicrobial peptide capable of disrupting the membrane integrity of microorganisms. Due to its membrane permeability, MAP-27 has inhibitory activity against both bacteria and cancer cells .
    BMAP-27
  • HY-P990280
    Anti-Mouse CD27 Antibody (RM27-3E5)

    		TNF Receptor Transmembrane Glycoprotein Inflammation/Immunology Cancer
    Anti-Mouse CD27 Antibody (RM27-3E5) is an agonistic rat-derived IgG2a κ type antibody, targeting to mouse CD27. Anti-Mouse CD27 Antibody (RM27-3E5) stimulates CD 27. Anti-Mouse CD27 Antibody (RM27-3E5) can be used for the researches of cancer and immunology, such as B16cOVA tumor .
    Anti-Mouse CD27 Antibody (RM27-3E5)
  • HY-124052
    AZ-27

    		RSV Infection
    AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter .
    AZ-27
  • HY-142003
    27-O-Demethylrapamycin

    		Fungal Infection
    27-O-Demethylrapamycin, a Rapamycin (HY-10219) derivative, is an antifungal agent. 27-O-Demethylrapamycin inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum .
    27-O-Demethylrapamycin
  • HY-124070
    ISA 27

    		MDM-2/p53 Cancer
    ISA 27 is a small-molecule MDM2-p53 protein-protein interaction inhibitor. ISA 27 inhibits MDM2-mediated p53 ubiquitination and degradation. ISA 27 is promising for research of p53-mutant solid tumors (e.g., thyroid, breast cancer) .
    ISA 27
  • HY-155115
    LSD1-IN-27
    1 Publications Verification

    		 Histone Demethylase PD-1/PD-L1 Cancer
    LSD1-IN-27 is an orally active LSD1 inhibitor (IC50: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer .
    LSD1-IN-27
  • HY-N11728
    2,7"-Phloroglucinol-6,6'-bieckol

    		Amylases Glycosidase Metabolic Disease
    2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC50 values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6, 6'-bieckol alleviates postprandial hyperglycemia in diabetic mice. 2,7"-Phloroglucinol-6,6'-bieckol can be used in diabetes research .
    2,7
  • HY-P99057A
    Varlilumab (anti-CD27)

    CDX-1127 (anti-CD27)

    		 TNF Receptor Transmembrane Glycoprotein Inflammation/Immunology Cancer
    Varlilumab (CDX-1127) (anti-CD27) is an agonist anti-CD27 monoclonal antibody. Varlilumab (anti-CD27) can promote T cell expansion and activate the immune response. Varlilumab (anti-CD27) has anti-tumor activity and can be used in the research of hematological malignancies and solid tumors .
    Varlilumab (anti-CD27)
  • HY-173509
    ATX inhibitor 27

    		Phosphodiesterase (PDE) LPL Receptor Infection Cardiovascular Disease Neurological Disease Cancer
    ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer .
    ATX inhibitor 27
  • HY-173603
    FAK-IN-27

    		FAK Cancer
    FAK-IN-27 (compound 8A) is a potent and selective FAK inhibitor with an IC50 of 4.968 nM. FAK-IN-27 suppresses H1299 cells proliferation with an IC50 of 0.28 μM. FAK-IN-27 can be used in the study of NSCLC .
    FAK-IN-27
  • HY-156553
    BTK-IN-27

    		Btk Inflammation/Immunology Cancer
    BTK-IN-27 (example 8) is a BTK inhibitor (IC50: 0.2 nM). BTK-IN-27 shows anti-proliferative activity in TMD8 cells (IC50: < 5 nM). BTK-IN-27 can be used for research of cancer, lymphoma, leukemia and immunological diseases .
    BTK-IN-27
  • HY-CE01171
    3-Oxo-27-methyloctacosanoyl-CoA

    3-Oxo-27-methyloctacosanoyl-coenzyme A

    		 Biochemical Assay Reagents Metabolic Disease
    3-Oxo-27-methyloctacosanoyl-CoA (3-Oxo-27-methyloctacosanoyl-coenzyme A) is a derivative of coenzyme A .
    3-Oxo-27-methyloctacosanoyl-CoA
  • HY-163457
    Antileishmanial agent-27

    		Aminoacyl-tRNA Synthetase Parasite Infection
    Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .
    Antileishmanial agent-27
  • HY-161179
    TRK-IN-27

    		Trk Receptor Cancer
    TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth .
    TRK-IN-27
  • HY-P2880
    PHI-27 (porcine)

    		GCGR Others
    PHI-27 (porcine) is a 27 amino acid peptide.PHI-27 (porcine) is used to find peptide hormones and other active peptides .
    PHI-27 (porcine)
  • HY-176728
    DHODH-IN-27

    		Dihydroorotate Dehydrogenase Infection
    DHODH-IN-27 (WF-8) is a dihydroacetate dehydrogenase (DHODH) inhibitor with an IC50 of 64.97 μM. DHODH-IN-27 can be used as an anti-DHODH herbicide .
    DHODH-IN-27
  • HY-165931
    Methyl 27-hydroxyheptacosanoate

    		Biochemical Assay Reagents Metabolic Disease
    Methyl 27-hydroxyheptacosanoate is an ester product.
    Methyl 27-hydroxyheptacosanoate
  • HY-144817
    Tubulin inhibitor 27

    		Microtubule/Tubulin Cancer
    Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC50 of 25.6 μM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities .
    Tubulin inhibitor 27
  • HY-172789
    mTOR inhibitor-27

    		mTOR Apoptosis Cancer
    mTOR inhibitor-27 (Compound 7e) is a mammalian target of rapamycin (mTOR) inhibitor with an IC50 value of 5.47 μM. mTOR inhibitor-27 can induce tumor cell apoptosis and arrest the cell cycle in the S-phase, thereby inhibiting cancer cell growth. mTOR inhibitor-27 is promising for research of cancers, such as skin cancer .
    mTOR inhibitor-27
  • HY-155069
    Antiproliferative agent-27

    		Apoptosis Cancer
    Antiproliferative agent-27 (compound 11) is an antiproliferative agent that significantly reduces the number of tumor cell colonies and induces apoptosis. Antiproliferative agent-27 has the potential to be used in the study of cancer .
    Antiproliferative agent-27
  • HY-155408
    ALR-27

    		FLAP Inflammation/Immunology
    ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .
    ALR-27
  • HY-D0323
    Vat Black 27

    		Fluorescent Dye
    Vat Black 27 is a black dye.
    Vat Black 27
  • HY-N1708
    27-Hydroxymangiferonic acid

    		Insecticide Parasite Others
    27-Hydroxymangiferonic acid is a Triterpenoids product that can be isolated from the herbs of Mangifera indica .
    27-Hydroxymangiferonic acid
  • HY-N10355
    27-TBDMS-4-Dehydrowithaferin A

    		Apoptosis Cancer
    27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .
    27-TBDMS-4-Dehydrowithaferin A
  • HY-N5046
    27-O-Acetyl-withaferin A

    		Others Inflammation/Immunology
    27-O-Acetyl-withaferin A is found in Withania aristata .
    27-O-Acetyl-withaferin A
  • HY-N10354
    27-Methyl withaferin A

    		Apoptosis Cancer
    27-Methyl withaferin A (comppund 26) is an apoptosis inducer with anticancer effects. 27-Methyl withaferin A shows antiproliferative effects against HeLa, A-549 and MCF-7 human tumor cell lines with IC50 values of 3.2 μM, 4.2 μM and 1.4 μM, respectively .
    27-Methyl withaferin A
  • HY-N10351
    27-O-(tert-Butyldimethylsilyl)withaferin A

    		Apoptosis Cancer
    27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .
    27-O-(tert-Butyldimethylsilyl)withaferin A
  • HY-W015451R
    2,7-Dihydroxynaphthalene (Standard)

    2,7-DHN (Standard); Naphthalene-2,7-diol (Standard)

    		 Reference Standards Fungal Others
    2,7-Dihydroxynaphthalene (Standard) (2,7-DHN (Standard)) is the analytical standard of 2,7-Dihydroxynaphthalene (HY-W015451). This product is intended for research and analytical applications. 2,7-Dihydroxynaphthalene (2,7-DHN) is a substrate of a new group of aromatic prenyltransferases in fungi and can be catalyzed to undergo a regiospecific prenylation reaction. 2,7-Dihydroxynaphthalene can undergo reactions such as oxidation and substitution .
    2,7-Dihydroxynaphthalene (Standard)

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