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SERPINB1 Antibody (YA7870)(PBS only)

(Synonyms: EI; ELANH2; HEL-S-27; HEL57; LEI; M/NEI; MNEI; PI-2; PI2)

SERPINB1 Antibody (YA7870) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERPINB1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, FC

  • Reactivity :

    Human, Dog, Monkey

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • SERPINB1 Antibody (YA7870)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:1000-4000 1:100-250 1:100

Product Details

Description

SERPINB1 Antibody (YA7870) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERPINB1.

  • Host Mouse
  • Species Reactivity
    Human, Dog, Monkey
  • Calculated Molecular Weight Predicted band size: 42.6 kDa
Immunogen

Human recombinant protein fragment corresponding to amino acids 77-306 of human SERPINB1 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    SERPINB1 is a Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function[1][2][3][4].

  • Subcellular Localization

    Secreted,Cytoplasm,Cytolytic granule,Early endosome

  • Expression


    Tissue_Specificity: In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes

  • Isoforms & Post-Translational Modification

    P30740 has two isomers: P30740-1: 42742 Da (predicted); P30740-2: 26073 Da (predicted).

  • Subunit

    Monomer (PubMed:23269243)

  • SwissProt ID

    P30740

  • Synonyms

    EI; ELANH2; HEL-S-27; HEL57; LEI; M/NEI; MNEI; PI-2; PI2

SERPINB1 Antibody (YA7870)(PBS only) Related Classifications

MOQ
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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • SERPINB1 Antibody (YA7870)(PBS only) Product Image