IMP-2552
IMP-2552 is a RAB27A/B inhibitor. IMP-2552 acts on the RAB27A/B effector protein-protein interaction, selectively modifying RAB27A/B-Cys123, but has no activity against RAB27A-Cys188. IMP-2552 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Formula: C25H26N6O5S
- Molecular Weight:522.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IMP-2552 (Compound 10) (2 h) potently inhibits the RAB27A-effector protein-protein interaction in a cell-free fluorescence polarization assay with an IC50 of 3.61 μM and a kinact/Ki of 32.1/M·s[1].
IMP-2552 (10 μM; 1 h) covalently and selectively modifies the Cys123 residue of recombinant RAB27A and RAB27B with equal potency against both active (GTP-bound) and inactive (GDP-bound) RAB27A, achieving 82.3% labeling of nRAB27A-Cys123 with minimal modification of Cys188[1].
IMP-2552 (10 μM; 2 h pre-incubation) stereoselectively engages endogenous RAB27A and RAB27B in MDA-MB-231 cells, competing for probe binding without affecting off-target proteins or inducing cytotoxicity[1].
IMP-2552 (10-20 μM; 14 h) disrupts the endogenous RAB27A-SLP2-A protein-protein interaction in MDA-MB-231 cells[1].
IMP-2552 (10 μM; 24 h) induces perinuclear melanosome clustering in melan-a mouse melanocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 522.58
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Formula C25H26N6O5S
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SMILES
O=S(C1=CC=C(NC(C=C)=O)C=C1)(N2CCC[C@@H]2C(NC3=CC=C(C(NC4=NN(C)C=C4)=O)C=C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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