(-)-JM-1232
(-)-JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia.
For research use only. We do not sell to patients.
- CAS No.: 1013427-48-9
- Formula: C24H27N3O2
- Molecular Weight:389.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1013427-48-9
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Molecular Weight 389.49
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Formula C24H27N3O2
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SMILES
O=C(N1CCN(CC1)C)C[C@@H]2C3=C(C=C4C(CCC4)=C3)C(N2C5=CC=CC=C5)=O
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Synonyms
MR04A3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nishiyama T, et al. Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats. Eur J Pharmacol. 2008 Oct 31;596(1-3):56-61. [Content Brief]
[2]. Chiba S, et al. The antinociceptive effects and pharmacological properties of JM-1232(-): a novel isoindoline derivative. Anesth Analg. 2009 Mar;108(3):1008-14. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(-)-JM-1232 Related Classifications
HY-108035 Related Classifications
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