1013427-48-9
Chemical Structure
(-)-JM-1232
Synonym(s): MR04A3
- CAS No.: 1013427-48-9
- Formula:C24H27N3O2
- Molecular Weight:389.49
IUPAC Name: (R)-3-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-2-phenyl-3,5,6,7-tetrahydrocyclopenta[f]isoindol-1(2H)-one
InChIKey: MBGOHVUPIPFVMM-JOCHJYFZSA-N
SMILES: O=C(N1CCN(CC1)C)C[C@@H]2C3=C(C=C4C(CCC4)=C3)C(N2C5=CC=CC=C5)=O
Biological Activity: (-)-JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia[1][2].
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(-)-JM-1232 | (-)-JM-1232 (MR04A3) targets GABA A receptors and exerts its analgesic effects by binding to the benzodiazepine binding site of GABA A receptors. (-)-JM-1232 demonstrates potent analgesic effects in mice against acute thermal stimuli, mechanically induced pain, and visceral pain, with CI50 values of 2.96, 3.06, and 2.27 mg/kg, respectively. (-)-JM-1232 can be used in research related to pain and analgesia. | |||||||||||||||||||||
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- [1]. Nishiyama T, et al. Antinociceptive property of intrathecal and intraperitoneal administration of a novel water-soluble isoindolin-1-one derivative, JM 1232 (-) in rats. Eur J Pharmacol. 2008 Oct 31;596(1-3):56-61. [Content Brief]
- [2]. Chiba S, et al. The antinociceptive effects and pharmacological properties of JM-1232(-): a novel isoindoline derivative. Anesth Analg. 2009 Mar;108(3):1008-14. [Content Brief]
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