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Lofepramine (Synonyms: Lopramine)

Cat. No.: HY-12390
Handling Instructions

Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties.

For research use only. We do not sell to patients.

Lofepramine Chemical Structure

Lofepramine Chemical Structure

CAS No. : 23047-25-8

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10 mM * 1 mL in DMSO USD 323 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Description

Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].

Molecular Weight

418.96

Formula

C₂₆H₂₇ClN₂O

CAS No.

23047-25-8

SMILES

CN(CC(C1=CC=C(Cl)C=C1)=O)CCCN2C3=CC=CC=C3CCC4=CC=CC=C42

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Lofepramine
Cat. No.:
HY-12390
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