CD27/TNFRSF7 Protein, Human (HEK293, His)
The CD27/TNFRSF7 protein is a receptor for CD70/CD27L and may ensure the survival of activated T cells, suggesting that it plays a crucial role in immune responses. Its association with SIVA1 suggests a regulatory function in the apoptotic pathway. CD27/TNFRSF7 Protein, Human (HEK293, His) is the recombinant human-derived CD27/TNFRSF7 protein, expressed by HEK293, with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The CD27/TNFRSF7 protein is a receptor for CD70/CD27L and may ensure the survival of activated T cells, suggesting that it plays a crucial role in immune responses. Its association with SIVA1 suggests a regulatory function in the apoptotic pathway. CD27/TNFRSF7 Protein, Human (HEK293, His) is the recombinant human-derived CD27/TNFRSF7 protein, expressed by HEK293, with C-His labeled tag.
Background
CD27/TNFRSF7 Protein, serving as the receptor for CD70/CD27L, potentially plays a critical role in the survival of activated T-cells, implicating its involvement in immune responses. Additionally, it may contribute to apoptosis through its association with SIVA1, suggesting a regulatory function in programmed cell death pathways. Existing as a homodimer, CD27/TNFRSF7 interacts with key proteins such as SIVA1 and TRAF2, indicating its engagement in intricate signaling cascades. The multifaceted roles of CD27/TNFRSF7 in T-cell survival and apoptosis underscore its significance in immune regulation and highlight its potential as a target for therapeutic interventions aimed at modulating immune responses.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His
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Accession
P26842 (T21-I192)
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Gene ID939
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Molecular Construction
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N-term
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CD27 (T21-I192)
Accession # P26842 -
His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
CD27; T-Cell Activation Antigen CD27; Prev. TNFRSF7; T14; CD27 Antigen; Tumor Necrosis Factor Receptor Superfamily Member 7; S152; T-Cell Activation Antigen S152; Tp55; T Cell Activation Antigen S152; Tumor Necrosis Factor Receptor Superfamily, Member 7;
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AA Sequence
TPAPKSCPERHYWAQGKLCCQMCEPGTFLVKDCDQHRKAAQCDPCIPGVSFSPDHHTRPHCESCRHCNSGLLVRNCTITANAECACRNGWQCRDKECTECDPLPNPSLTARSSQALSPHPQPTHLPYVSEMLEARTAGHMQTLADFRQLPARTLSTHWPPQRSLCSSDFIRI
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Predicted Molecular Mass
18.1 kDa
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Molecular Weight
Approximately 40-60 kDa,based on Bis-Tris PAGE under reducing conditions,due to the glycosylation.
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Glycosylation
Yes
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Structure/Form
Monomer
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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