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Cat. No.: HY-161697

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hCAIX-IN-20

hCAIX-IN-20 (compound APBS-5m) is a potent inhibitor of carbonic anhydrase IX (hCA IX), with the K_i of 2.7 nM. hCAIX-IN-20 plays an important role in cancer research.

For research use only. We do not sell to patients.

CAS No.: 3047054-26-9
Formula: C₁₉H₁₃Cl₂N₅O₄S₂
Molecular Weight:510.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

hCAIX-IN-20 Chemical Structure

CAS No.: 3047054-26-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Biological Activity

Description

hCAIX-IN-20 (compound APBS-5m) is a potent inhibitor of carbonic anhydrase IX (hCA IX), with the K_i of 2.7 nM. hCAIX-IN-20 plays an important role in cancer research^[1].

All Carbonic Anhydrase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.73 μM Compound: 5m	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay	[PMID: 38810335]
HCT-116	IC₅₀	3.65 μM Compound: 5m	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay	[PMID: 38810335]
HeLa	IC₅₀	3.65 μM Compound: 5m	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay	[PMID: 38810335]
MCF-10A	IC₅₀	45.1 μM Compound: 5m	Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay	[PMID: 38810335]
MDA-MB-231	IC₅₀	2.93 μM Compound: 5m	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by sulphorhodamine-B assay	[PMID: 38810335]

Chemical Information

CAS No. 3047054-26-9
Molecular Weight 510.37
Formula C₁₉H₁₃Cl₂N₅O₄S₂
SMILES

ClC1=C(Cl)C(C2=C(C#N)C(O)=NC(SCC(NC3=CC=C(S(N)(=O)=O)C=C3)=O)=N2)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Salma M Hefny, et al. A new framework for novel analogues of pazopanib as potent and selective human carbonic anhydrase inhibitors: Design, repurposing rational, synthesis, crystallographic, in vivo and in vitro biological assessments. Eur J Med Chem. 2024 Aug 5:274:116527. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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References

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hCAIX-IN-20

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAIX-IN-20 Related Classifications

HY-161697 Related Classifications