ASIC1a antagonist-1
Based on 1 Customer Validation
ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC50 of 27 nM (pH 6.7). ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 1787243-08-6
- Formula: C23H29Cl3N4O2
- Molecular Weight:499.86
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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ASIC1a 27 nM (IC50) |
Chemical Information
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CAS No. 1787243-08-6
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Appearance Solid
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Molecular Weight 499.86
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Formula C23H29Cl3N4O2
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Color Light yellow to yellow
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SMILES
O=C1OC2=C(C=C1C(N)=N)C=CC(N(CCN(CC)CC)CC3=CC=C(C=C3)Cl)=C2.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (200.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0006 mL | 10.0028 mL | 20.0056 mL | 50.0140 mL |
| 5 mM | 0.4001 mL | 2.0006 mL | 4.0011 mL | 10.0028 mL | |
| 10 mM | 0.2001 mL | 1.0003 mL | 2.0006 mL | 5.0014 mL | |
| 15 mM | 0.1334 mL | 0.6669 mL | 1.3337 mL | 3.3343 mL | |
| 20 mM | 0.1000 mL | 0.5001 mL | 1.0003 mL | 2.5007 mL | |
| 25 mM | 0.0800 mL | 0.4001 mL | 0.8002 mL | 2.0006 mL | |
| 30 mM | 0.0667 mL | 0.3334 mL | 0.6669 mL | 1.6671 mL | |
| 40 mM | 0.0500 mL | 0.2501 mL | 0.5001 mL | 1.2504 mL | |
| 50 mM | 0.0400 mL | 0.2001 mL | 0.4001 mL | 1.0003 mL | |
| 60 mM | 0.0333 mL | 0.1667 mL | 0.3334 mL | 0.8336 mL | |
| 80 mM | 0.0250 mL | 0.1250 mL | 0.2501 mL | 0.6252 mL | |
| 100 mM | 0.0200 mL | 0.1000 mL | 0.2001 mL | 0.5001 mL |
ASIC1a antagonist-1 Related Classifications
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