GPX4-IN-23
GPX4-IN-23 (Compound 3e) is a GPX4 inhibitor with an IC50 of 0.27 μM. GPX4-IN-23 induces Ferroptosis by enhancing lipid peroxidation, ROS production, and intracellular GSH depletion. GPX4-IN-23 exhibits antiproliferative activity against central nervous system cancer cells. GPX4-IN-23 can be used in studies related to central nervous system cancers.
For research use only. We do not sell to patients.
- Formula: C24H25N5O
- Molecular Weight:399.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GPX4 0.27 μM (IC50) |
GPX4-IN-23 potently inhibits recombinant GPX4 enzyme, with an IC50 of 0.27 μM[1].
GPX4-IN-23 (48 h) potently inhibits the proliferation of SNB-75 central nervous system cancer cells, with an IC50 of 3.22 μM[1].
GPX4-IN-23 (0.3-0.6 μM) increases the level of lipid peroxidation in SNB-75 central nervous system cancer cells in a concentration-dependent manner, with MDA levels increased by 2.5-fold and 3.5-fold at concentrations of 0.3 μM and 0.6 μM, respectively[1].
GPX4-IN-23 (0.3-0.6 μM) dose-dependently depletes glutathione in SNB-75 CNS cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 399.49
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Formula C24H25N5O
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SMILES
O=C(NC1=CC=CC=C1)NC2=CC=C(/C(C)=N/N=C/C3=CC=C(N(C)C)C=C3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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