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Cat. No.: HY-148641

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ZJH-16

ZJH-16 (Compound 11e) is an orally active EED inhibitor (IC₅₀ = 2.72 nM, K_d = 4.4 nM). ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2877017-58-6
Formule: C₁₈H₁₄N₆O
Masse moléculaire:330.34

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ZJH-16 Chemical Structure

CAS No.: 2877017-58-6

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	IC₅₀	0.22 μM Compound: 11e; ZJH-16	Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay	[PMID: 36580346]
Pfeiffer	IC₅₀	0.13 μM Compound: 11e; ZJH-16	Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay	[PMID: 36580346]

Chemical Information

CAS No. 2877017-58-6
Masse moléculaire 330.34
Formule C₁₈H₁₄N₆O
SMILES

C12=CC=CC(C3=CN=C(N4C3=NN=C4)NCC5=CC=CO5)=C1NC=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Dong G, et al. Structure-Based Design of the Indole-Substituted Triazolopyrimidines as New EED-H3K27me3 Inhibitors for the Treatment of Lymphoma. J Med Chem. 2023 Jan 12;66(1):1063-1081. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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