ZJH-16
ZJH-16 (Compound 11e) is an orally active EED inhibitor (IC50 = 2.72 nM, Kd = 4.4 nM). ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers.
For research use only. We do not sell to patients.
- CAS No.: 2877017-58-6
- Formula: C18H14N6O
- Molecular Weight:330.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Histone Methyltransferase Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KARPAS-422 | IC50 |
0.22 μM
Compound: 11e; ZJH-16
|
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
|
[PMID: 36580346] |
| Pfeiffer | IC50 |
0.13 μM
Compound: 11e; ZJH-16
|
Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
Antiproliferative activity against human Pfeiffer cells assessed as cell growth inhibition incubated for 7 days by CCK-8 assay
|
[PMID: 36580346] |
Chemical Information
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CAS No. 2877017-58-6
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Molecular Weight 330.34
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Formula C18H14N6O
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SMILES
C12=CC=CC(C3=CN=C(N4C3=NN=C4)NCC5=CC=CO5)=C1NC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)