2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. Ferroptosis-IN-27

Ferroptosis-IN-27 is a glutathione peroxidase (GPx) mimetic. Ferroptosis-IN-27 inhibits oxidative stress, reduces intracellular ROS levels, decreases lipid peroxidation and alleviates ferrous ion overload, thereby inhibiting ferroptosis and protecting cardiomyocytes from Doxorubicin (HY-15142A)-induced injury. Ferroptosis-IN-27 can be used in studies related to Doxorubicin-induced cardiotoxicity.

For research use only. We do not sell to patients.

Ferroptosis-IN-27

Ferroptosis-IN-27 Chemical Structure

CAS No. : 3030492-72-6

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Ferroptosis-IN-27 Related Antibodies

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Description

Ferroptosis-IN-27 is a glutathione peroxidase (GPx) mimetic. Ferroptosis-IN-27 inhibits oxidative stress, reduces intracellular ROS levels, decreases lipid peroxidation and alleviates ferrous ion overload, thereby inhibiting ferroptosis and protecting cardiomyocytes from Doxorubicin (HY-15142A)-induced injury. Ferroptosis-IN-27 can be used in studies related to Doxorubicin-induced cardiotoxicity[1].

In Vitro

Ferroptosis-IN-27 (Compound 7) (0.8-20 μM; 24 h) protects H9C2 cardiomyocytes against Doxorubicin-induced injury in a concentration-dependent manner, acting via alleviating oxidative stress and reducing ferrous ion overload[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis-IN-27 Related Antibodies

Cell Viability Assay[1]

Cell Line: H9C2 cardiomyocytes
Concentration: 0.8 μM, 4 μM, 20 μM
Incubation Time: 24 h
Result: Increased cell viability in a concentration-dependent manner at all tested concentrations, preventing 75% of doxorubicin-induced cell viability loss at 20 μM.
Significantly reduced intracellular malondialdehyde (MDA) levels at 4 μM compared to the doxorubicin-alone group.
Inhibited intracellular reactive oxygen species (ROS) production at 4 μM compared to the doxorubicin-alone group.
Reversed doxorubicin-induced ferrous ion (Fe2+) accumulation at 4 μM compared to the doxorubicin-alone group.
Molecular Weight

397.08

Formula

C14H8BrNO3Se
CAS No.
SMILES

O=C(O)C1=CC=CC(N2[Se]C3=C(Br)C=CC=C3C2=O)=C1
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Ferroptosis-IN-27 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis-IN-273030492-72-6FerroptosisGlutathione PeroxidaseReactive Oxygen Species (ROS)hydroperoxide reductionlipid peroxidationreactive oxygen speciesselenenyl sulfide intermediatesferroptosisoxidative stresscardiomyocytesglutathione peroxidaseGPxH9C2 cardiomyocytesInhibitorinhibitorinhibit

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