Ferroptosis-IN-27
Ferroptosis-IN-27 is a glutathione peroxidase (GPx) mimetic. Ferroptosis-IN-27 inhibits oxidative stress, reduces intracellular ROS levels, decreases lipid peroxidation and alleviates ferrous ion overload, thereby inhibiting ferroptosis and protecting cardiomyocytes from Doxorubicin (HY-15142A)-induced injury. Ferroptosis-IN-27 can be used in studies related to Doxorubicin-induced cardiotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 3030492-72-6
- Formula: C14H8BrNO3Se
- Molecular Weight:397.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ferroptosis-IN-27 (Compound 7) (0.8-20 μM; 24 h) protects H9C2 cardiomyocytes against Doxorubicin-induced injury in a concentration-dependent manner, acting via alleviating oxidative stress and reducing ferrous ion overload[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H9C2 cardiomyocytes
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Concentration:0.8 μM, 4 μM, 20 μM
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Incubation Time:24 h
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Result:Increased cell viability in a concentration-dependent manner at all tested concentrations, preventing 75% of doxorubicin-induced cell viability loss at 20 μM.
Significantly reduced intracellular malondialdehyde (MDA) levels at 4 μM compared to the doxorubicin-alone group.
Inhibited intracellular reactive oxygen species (ROS) production at 4 μM compared to the doxorubicin-alone group.
Reversed doxorubicin-induced ferrous ion (Fe2+) accumulation at 4 μM compared to the doxorubicin-alone group.
Chemical Information
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CAS No. 3030492-72-6
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Molecular Weight 397.08
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Formula C14H8BrNO3Se
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SMILES
O=C(O)C1=CC=CC(N2[Se]C3=C(Br)C=CC=C3C2=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ferroptosis-IN-27 Related Classifications
HY-183567 Related Classifications
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