SERPINB1 Antibody (YA7870)
(Synonyms: EI; ELANH2; HEL-S-27; HEL57; LEI; M/NEI; MNEI; PI-2; PI2)SERPINB1 Antibody (YA7870) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERPINB1.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Dog, Monkey
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:1000-4000 | 1:100-250 | 1:100 |
Product Details
SERPINB1 Antibody (YA7870) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to SERPINB1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Monkey
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Calculated Molecular Weight Predicted band size: 42.6 kDa
Human recombinant protein fragment corresponding to amino acids 77-306 of human SERPINB1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SERPINB1 is a Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function[1][2][3][4].
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Subcellular Localization
Secreted,Cytoplasm,Cytolytic granule,Early endosome
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Expression
Tissue_Specificity: In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes -
Isoforms & Post-Translational Modification
P30740 has two isomers: P30740-1: 42742 Da (predicted); P30740-2: 26073 Da (predicted).
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Subunit
Monomer (PubMed:23269243)
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SwissProt ID
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Synonyms
EI; ELANH2; HEL-S-27; HEL57; LEI; M/NEI; MNEI; PI-2; PI2
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