SOX15 Antibody
(Synonyms: SOX12, SOX20, SOX26, SOX27, SOX15, Transcription factor SOX-15, Protein SOX-12, Protein SOX-20, SRY-box transcription factor 15)SOX15 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SOX15.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
SOX15 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SOX15.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 32 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 25 kDa
Synthetic peptide corresponding to the Central region of human SOX15.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SOX15 is a Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity). Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity). Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity). Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity). Regulates transcription of HRC via binding to it proximal enhancer region (By similarity). Involved in skeletal muscle regeneration (By similarity). Also plays a role in the development of myogenic precursor cells (By similarity)
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. -
Isoforms & Post-Translational Modification
SOX15 has 2 isoforms, O60248-1: amino acid length is 233, molecular weight is 25251 Da (predicted); O60248-2: amino acid length is 178, molecular weight is 19393 Da (predicted).
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Subunit
Interacts with HAND1; the interaction enhances HAND1-induced differentiation of trophoblast giant cells (By similarity).
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SwissProt ID
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Synonyms
SOX12, SOX20, SOX26, SOX27, SOX15, Transcription factor SOX-15, Protein SOX-12, Protein SOX-20, SRY-box transcription factor 15
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