TPG-20A
TPG-20A is a SARS-CoV-2 main protease inhibitor with an IC50 of 27.8 nM. TPG-20A also inhibits MERS-CoV main protease. TPG-20A can be used for the research of infection, such as SARS-CoV-2.
For research use only. We do not sell to patients.
- Formula: C24H27Cl2N5O5
- Molecular Weight:536.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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SARS-CoV-2 27.8 nM (IC50) |
TPG-20A (Compound 20a) shows EC50 values of 3.9 and 0.46 μM against SARS-CoV-2WK-521-exposed VeroE6 cells or SARS-CoV-2BQ.1.1-exposed HeLaACE2-TMPRSS2 cells[1].
TPG-20A shows CC50 values >100 μM against VeroE6 and HeLaACE2-TMPRSS2 cells[1].
TPG-20A shows IC50 values of 7.1 and 42.9 nM against SARS-CoV-2 Mpro and MERS-CoV Mpro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 536.41
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Formula C24H27Cl2N5O5
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SMILES
O=C(C(N1)=CC2=C1C=CC=C2OC)N[C@@H](CC(C)C)C(NN(C(C(Cl)Cl)=O)CC3=CC=CNC3=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TPG-20A Related Classifications
HY-178188 Related Classifications
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