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Cat. No.: HY-128408

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PROTAC BTK Degrader-4

PROTAC BTK Degrader-4 (compound 15) is a potent PROTAC Bruton's tyrosine kinases (BTK) degrader (DC₅₀ < 100 nM) with little immunomodulatory imide drug (IMiD) activity (DC₅₀ = 0.345 μM, D_max = 27.4%). PROTAC BTK Degrader-4 can be used for cancers, autoimmune diseases, and inflammatory diseases that are mediated by BTK.
(Pink: Btk ligand (HY-170324); Blue: Cereblon E3 ligase ligand; Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2893795-12-3
Formula: C₄₂H₅₄N₁₂O₅
Molecular Weight:806.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PROTAC BTK Degrader-4 Chemical Structure

CAS No.: 2893795-12-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC BTK Degrader-4 (compound 15) is a potent PROTAC Bruton's tyrosine kinases (BTK) degrader (DC₅₀ < 100 nM) with little immunomodulatory imide drug (IMiD) activity (DC₅₀ = 0.345 μM, D_max = 27.4%). PROTAC BTK Degrader-4 can be used for cancers, autoimmune diseases, and inflammatory diseases that are mediated by BTK^[1]. (Pink: Btk ligand (HY-170324); Blue: Cereblon E3 ligase ligand; Black: linker).

All PROTACs Isoforms :

Chemical Information

CAS No. 2893795-12-3
Molecular Weight 806.96
Formula C₄₂H₅₄N₁₂O₅
SMILES

O=C(C1=NC=C(N2C[C@H](N3CCN(C)C3=O)CCC2)N=C1NC4=CC=C(C5CCN(CC6CCN(C7=CC=C(C(NC(CC8)C(NC8=O)=O)=O)N=C7)CC6)CC5)C=C4)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cristiana Guiducci, et al. Bifunctional compounds for degrading btk with diminished imid activity. WO2023287928. 2023-01-19.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PROTAC BTK Degrader-4

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BTK Degrader-4 Related Classifications

HY-128408 Related Classifications