2893795-12-3
Chemical Structure
PROTAC BTK Degrader-4
- CAS No.: 2893795-12-3
- Formula:C42H54N12O5
- Molecular Weight:806.96
IUPAC Name: 3-((4-(1-((1-(6-((2,6-dioxopiperidin-3-yl)carbamoyl)pyridin-3-yl)piperidin-4-yl)methyl)piperidin-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl)pyrazine-2-carboxamide
InChIKey: HPTPDBYCFHFWJG-GAWVXTGCSA-N
SMILES: O=C(C1=NC=C(N2C[C@H](N3CCN(C)C3=O)CCC2)N=C1NC4=CC=C(C5CCN(CC6CCN(C7=CC=C(C(NC(CC8)C(NC8=O)=O)=O)N=C7)CC6)CC5)C=C4)N
Biological Activity: PROTAC BTK Degrader-4 (compound 15) is a potent PROTAC Bruton's tyrosine kinases (BTK) degrader (DC50 < 100 nM) with little immunomodulatory imide drug (IMiD) activity (DC50 = 0.345 μM, Dmax = 27.4%). PROTAC BTK Degrader-4 can be used for cancers, autoimmune diseases, and inflammatory diseases that are mediated by BTK[1].
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PROTAC BTK Degrader-4 | PROTAC BTK Degrader-4 (compound 15) is a potent PROTAC Bruton's tyrosine kinases (BTK) degrader (DC50 < 100 nM) with little immunomodulatory imide drug (IMiD) activity (DC50 = 0.345 μM, Dmax = 27.4%). PROTAC BTK Degrader-4 can be used for cancers, autoimmune diseases, and inflammatory diseases that are mediated by BTK. | |||||||||||||||||||||
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Keywords
